% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Belitsky:865025,
      author       = {Belitsky, V. and Schütz, G. M.},
      title        = {{RNA} polymerase interactions and elongation rate},
      journal      = {Journal of theoretical biology},
      volume       = {462},
      issn         = {0022-5193},
      address      = {Amsterdam},
      publisher    = {Elsevier Ltd.},
      reportid     = {FZJ-2019-04590},
      pages        = {370-380},
      year         = {2019},
      abstract     = {We show that non-steric molecular interactions between RNA
                      polymerase (RNAP) motors that move simultaneously on the
                      same DNA track determine strongly the kinetics of
                      transcription elongation. With a focus on the role of
                      collisions and cooperation, we introduce a stochastic model
                      that allows for the exact analytical computation of the
                      stationary properties of transcription elongation as a
                      function of RNAP density, their interaction strength,
                      nucleoside triphosphate concentration, and rate of
                      pyrophosphate release. Cooperative pushing, i.e., an
                      enhancement of the average RNAP velocity and elongation
                      rate, arises due to stochastic pushing which cannot be
                      explained by steric hindrance alone. The cooperative effect
                      requires a molecular repulsion in excess of a critical
                      strength and disappears beyond a critical RNAP density,
                      above which jamming due to collisions takes over. For strong
                      repulsion and at the same time strong stochastic blocking,
                      cooperative pushing at low RNAP densities is suppressed, but
                      a reentrance regime at higher densities appears.},
      cin          = {ICS-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-2-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30496746},
      UT           = {WOS:000455972600031},
      doi          = {10.1016/j.jtbi.2018.11.025},
      url          = {https://juser.fz-juelich.de/record/865025},
}