TY  - JOUR
AU  - Rabenstein, Monika
AU  - Unverricht-Yeboah, Marcus
AU  - Keuters, Meike Hedwig
AU  - Pikhovych, Anton
AU  - Hucklenbroich, Joerg
AU  - Vay, Sabine Ulrike
AU  - Blaschke, Stefan
AU  - Ladwig, Anne
AU  - Walter, Helene Luise
AU  - Beiderbeck, Magdalena
AU  - Fink, Gereon Rudolf
AU  - Schroeter, Michael
AU  - Kriehuber, Ralf
AU  - Rueger, Maria Adele
TI  - Transcranial Current Stimulation Alters the Expression of Immune-Mediating Genes
JO  - Frontiers in cellular neuroscience
VL  - 13
SN  - 1662-5102
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - FZJ-2019-05297
SP  - 461
PY  - 2019
AB  - Despite its extensive use in clinical studies, the molecular mechanisms underlying the effects of transcranial direct current stimulation (tDCS) remain to be elucidated. We previously described subacute effects of tDCS on immune- and stem cells in the rat brain. To investigate the more immediate effects of tDCS regulating those cellular responses, we treated rats with a single session of either anodal or cathodal tDCS, and analyzed the gene expression by microarray; sham-stimulated rats served as control. Anodal tDCS increased expression of several genes coding for the major histocompatibility complex I (MHC I), while cathodal tDCS increased the expression of the immunoregulatory protein osteopontin (OPN). We confirmed the effects of gene upregulation by immunohistochemistry at the protein level. Thus, our data show a novel mechanism for the actions of tDCS on immune- and inflammatory processes, providing a target for future therapeutic studies.
LB  - PUB:(DE-HGF)16
C6  - pmid:31708742
UR  - <Go to ISI:>//WOS:000496432500001
DO  - DOI:10.3389/fncel.2019.00461
UR  - https://juser.fz-juelich.de/record/866056
ER  -