Journal Article

FZJ-2019-05297

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Transcranial Current Stimulation Alters the Expression of Immune-Mediating Genes

Rabenstein, M. ; Unverricht-Yeboah, M. ; Keuters, M. H. ; Pikhovych, A. ; Hucklenbroich, J.FZJ* ; Vay, S. U. ; Blaschke, S.FZJ* ; Ladwig, A. ; Walter, H. L. ; Beiderbeck, M. ; Fink, G. R.FZJ* ; Schroeter, M.FZJ* ; Kriehuber, R.FZJ* ; Rueger, M. A. (Corresponding author)FZJ*

2019
Frontiers Research Foundation Lausanne

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Please use a persistent id in citations: http://hdl.handle.net/2128/23179  doi:10.3389/fncel.2019.00461

Abstract: Despite its extensive use in clinical studies, the molecular mechanisms underlying the effects of transcranial direct current stimulation (tDCS) remain to be elucidated. We previously described subacute effects of tDCS on immune- and stem cells in the rat brain. To investigate the more immediate effects of tDCS regulating those cellular responses, we treated rats with a single session of either anodal or cathodal tDCS, and analyzed the gene expression by microarray; sham-stimulated rats served as control. Anodal tDCS increased expression of several genes coding for the major histocompatibility complex I (MHC I), while cathodal tDCS increased the expression of the immunoregulatory protein osteopontin (OPN). We confirmed the effects of gene upregulation by immunohistochemistry at the protein level. Thus, our data show a novel mechanism for the actions of tDCS on immune- and inflammatory processes, providing a target for future therapeutic studies.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)
2. Sicherheit und Strahlenschutz, Umgebungsüberwachung,Strahlenbiologie (S-US)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)

Appears in the scientific report 2019

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Database coverage:
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