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@ARTICLE{Rabenstein:866056,
author = {Rabenstein, Monika and Unverricht-Yeboah, Marcus and
Keuters, Meike Hedwig and Pikhovych, Anton and
Hucklenbroich, Joerg and Vay, Sabine Ulrike and Blaschke,
Stefan and Ladwig, Anne and Walter, Helene Luise and
Beiderbeck, Magdalena and Fink, Gereon Rudolf and Schroeter,
Michael and Kriehuber, Ralf and Rueger, Maria Adele},
title = {{T}ranscranial {C}urrent {S}timulation {A}lters the
{E}xpression of {I}mmune-{M}ediating {G}enes},
journal = {Frontiers in cellular neuroscience},
volume = {13},
issn = {1662-5102},
address = {Lausanne},
publisher = {Frontiers Research Foundation},
reportid = {FZJ-2019-05297},
pages = {461},
year = {2019},
abstract = {Despite its extensive use in clinical studies, the
molecular mechanisms underlying the effects of transcranial
direct current stimulation (tDCS) remain to be elucidated.
We previously described subacute effects of tDCS on immune-
and stem cells in the rat brain. To investigate the more
immediate effects of tDCS regulating those cellular
responses, we treated rats with a single session of either
anodal or cathodal tDCS, and analyzed the gene expression by
microarray; sham-stimulated rats served as control. Anodal
tDCS increased expression of several genes coding for the
major histocompatibility complex I (MHC I), while cathodal
tDCS increased the expression of the immunoregulatory
protein osteopontin (OPN). We confirmed the effects of gene
upregulation by immunohistochemistry at the protein level.
Thus, our data show a novel mechanism for the actions of
tDCS on immune- and inflammatory processes, providing a
target for future therapeutic studies.},
cin = {INM-3 / S-US},
ddc = {610},
cid = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)S-US-20090406},
pnm = {572 - (Dys-)function and Plasticity (POF3-572)},
pid = {G:(DE-HGF)POF3-572},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:31708742},
UT = {WOS:000496432500001},
doi = {10.3389/fncel.2019.00461},
url = {https://juser.fz-juelich.de/record/866056},
}