TY  - JOUR
AU  - Fejzagic, Alexander
AU  - Gebauer, Jan
AU  - Huwa, Nikolai
AU  - Classen, Thomas
TI  - Halogenating Enzymes for Active Agent Synthesis: First Steps are done, Many have to follow
JO  - Molecules
VL  - 24
IS  - 21
SN  - 1420-3049
CY  - Basel
PB  - MDPI
M1  - FZJ-2019-05330
SP  - 4008 -
PY  - 2019
AB  - Halogens can be very important for active agents as vital parts of their binding mode, on the one hand, but are on the other hand instrumental in the synthesis of most active agents. However, the primary halogenating compound is molecular chlorine which has two major drawbacks, high energy consumption and hazardous handling. Nature bypassed molecular halogens and evolved at least six halogenating enzymes: Three kind of haloperoxidases, flavin-dependent halogenases as well as α-ketoglutarate and S-adenosylmethionine (SAM)-dependent halogenases. This review shows what is known today on these enzymes in terms of biocatalytic usage. The reader may understand this review as a plea for the usage of halogenating enzymes for fine chemical syntheses, but there are many steps to take until halogenating enzymes are reliable, flexible, and sustainable catalysts for halogenation.
LB  - PUB:(DE-HGF)16
C6  - pmid:31694313
UR  - <Go to ISI:>//WOS:000498055500197
DO  - DOI:10.3390/molecules24214008
UR  - https://juser.fz-juelich.de/record/866111
ER  -