Journal Article

FZJ-2019-05330

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Halogenating Enzymes for Active Agent Synthesis: First Steps are done, Many have to follow

Fejzagic, A.FZJ* ; Gebauer, J.FZJ* ; Huwa, N.FZJ* ; Classen, T. (Corresponding author)FZJ*

2019
MDPI Basel

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Please use a persistent id in citations: http://hdl.handle.net/2128/24009  doi:10.3390/molecules24214008

Abstract: Halogens can be very important for active agents as vital parts of their binding mode, on the one hand, but are on the other hand instrumental in the synthesis of most active agents. However, the primary halogenating compound is molecular chlorine which has two major drawbacks, high energy consumption and hazardous handling. Nature bypassed molecular halogens and evolved at least six halogenating enzymes: Three kind of haloperoxidases, flavin-dependent halogenases as well as α-ketoglutarate and S-adenosylmethionine (SAM)-dependent halogenases. This review shows what is known today on these enzymes in terms of biocatalytic usage. The reader may understand this review as a plea for the usage of halogenating enzymes for fine chemical syntheses, but there are many steps to take until halogenating enzymes are reliable, flexible, and sustainable catalysts for halogenation.

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Contributing Institute(s):

1. Biotechnologie (IBG-1)
2. Institut für Bioorganische Chemie (HHUD) (IBOC)

Research Program(s):

1. 583 - Innovative Synergisms (POF3-583) (POF3-583)
2. DFG project 369034981 - Mechanismen der durch Dirigent/Jacalin-Proteinpaare hervorgerufenen Breitspektrumresistenz in Pflanzen gegen pilzliche Pathogene (369034981)

Appears in the scientific report 2019

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Database coverage:
; ; ; ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; DOAJ Seal ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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