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@ARTICLE{Fejzagic:866111,
      author       = {Fejzagic, Alexander and Gebauer, Jan and Huwa, Nikolai and
                      Classen, Thomas},
      title        = {{H}alogenating {E}nzymes for {A}ctive {A}gent {S}ynthesis:
                      {F}irst {S}teps are done, {M}any have to follow},
      journal      = {Molecules},
      volume       = {24},
      number       = {21},
      issn         = {1420-3049},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2019-05330},
      pages        = {4008 -},
      year         = {2019},
      abstract     = {Halogens can be very important for active agents as vital
                      parts of their binding mode, on the one hand, but are on the
                      other hand instrumental in the synthesis of most active
                      agents. However, the primary halogenating compound is
                      molecular chlorine which has two major drawbacks, high
                      energy consumption and hazardous handling. Nature bypassed
                      molecular halogens and evolved at least six halogenating
                      enzymes: Three kind of haloperoxidases, flavin-dependent
                      halogenases as well as α-ketoglutarate and
                      S-adenosylmethionine (SAM)-dependent halogenases. This
                      review shows what is known today on these enzymes in terms
                      of biocatalytic usage. The reader may understand this review
                      as a plea for the usage of halogenating enzymes for fine
                      chemical syntheses, but there are many steps to take until
                      halogenating enzymes are reliable, flexible, and sustainable
                      catalysts for halogenation.},
      cin          = {IBG-1 / IBOC},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBG-1-20101118 / I:(DE-Juel1)IBOC-20090406},
      pnm          = {583 - Innovative Synergisms (POF3-583) / DFG project
                      369034981 - Mechanismen der durch
                      Dirigent/Jacalin-Proteinpaare hervorgerufenen
                      Breitspektrumresistenz in Pflanzen gegen pilzliche
                      Pathogene},
      pid          = {G:(DE-HGF)POF3-583 / G:(GEPRIS)369034981},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31694313},
      UT           = {WOS:000498055500197},
      doi          = {10.3390/molecules24214008},
      url          = {https://juser.fz-juelich.de/record/866111},
}