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@ARTICLE{Achillles:867482,
      author       = {Achillles, Nils and Pasch, Norbert and Lintermann, Andreas
                      and Schröder, Wolfgang and Mösges, Ralph},
      title        = {{C}omputational fluid dynamics: a suitable assessment tool
                      for demonstrating the antiobstructive effect of drugs in the
                      therapy of allergic rhinitis},
      journal      = {Acta oto-laryngologica},
      volume       = {33},
      number       = {1},
      issn         = {0001-6489},
      publisher    = {Taylor Francis Group},
      reportid     = {FZJ-2019-06121},
      pages        = {36-42},
      year         = {2013},
      abstract     = {This systematic review aims first to summarize the previous
                      areas of application of computational fluid dynamics (CFD)
                      and then to demonstrate that CFD is also a suitable
                      instrument for generating three-dimensional images that
                      depict drug effects on nasal mucosa. Special emphasis is
                      placed on the three-dimensional visualization of the
                      antiobstructive effect of nasal steroids and antihistamines
                      in the treatment of allergic rhinitis. In the beginning, CFD
                      technology was only used to demonstrate physiological and
                      pathophysiological airflow conditions in the nose and to aid
                      in preoperative planning and postoperative monitoring of
                      surgical outcome in the field of rhinosurgery. The first
                      studies using CFD examined nasal respiratory physiology,
                      important functions of the nose, such as conditioning and
                      warming of inspired air, and the influence of
                      pathophysiological changes on nasal breathing. Also,
                      postoperative outcome of surgical procedures could be
                      "predicted" using the nasal airflow model. Later studies
                      focused on the three-dimensional visualization of the effect
                      of nasal sprays in healthy subjects and postoperative
                      patients. A completely new approach, however, was the use of
                      CFD in the area of allergic rhinitis and the treatment of
                      its cardinal symptom of nasal obstruction. In two clinical
                      trials, a suitable patient with a positive history of
                      allergic rhinitis was enrolled during a symptom-free period
                      after the pollen season. The patient developed typical
                      allergic rhinitis symptoms after provocation with birch
                      pollen. The 3-D visualization showed that the antiallergic
                      treatment successfully counteracted the effects of nasal
                      allergen provocation on nasal airflow. These observations
                      were attributed to the antiobstructive effect of a nasal
                      steroid (mometasone furoate) and a systemic antihistamine
                      (levocetirizine), respectively. CFD therefore constitutes a
                      non-invasive, precise, reliable and objective examination
                      procedure for generating three-dimensional images that
                      depict the effects of drugs used in the treatment of
                      allergic rhinitis. Abstract available from the publisher.},
      ddc          = {610},
      pnm          = {511 - Computational Science and Mathematical Methods
                      (POF3-511)},
      pid          = {G:(DE-HGF)POF3-511},
      typ          = {PUB:(DE-HGF)16},
      url          = {https://juser.fz-juelich.de/record/867482},
}