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@ARTICLE{AbaurreaVelasco:867555,
      author       = {Abaurrea-Velasco, Clara and Auth, Thorsten and Gompper,
                      Gerhard},
      title        = {{V}esicles with internal active filaments: self-organized
                      propulsion controls shape, motility, and dynamical response},
      journal      = {New journal of physics},
      volume       = {21},
      issn         = {1367-2630},
      address      = {[London]},
      publisher    = {IOP},
      reportid     = {FZJ-2019-06178},
      pages        = {123024},
      year         = {2019},
      abstract     = {Self-propulsion and navigation due to the sensing of
                      environmental conditions --- such as durotaxis and
                      chemotaxis --- are remarkable properties of biological cells
                      that cannot be modeled by single-component self-propelled
                      particles. Therefore, we introduce and study "flexocytes",
                      deformable vesicles with enclosed attached self-propelled
                      pushing and pulling filaments that align due to steric and
                      membrane-mediated interactions. Using computer simulations
                      in two dimensions, we show that the membrane deforms under
                      the propulsion forces and forms shapes mimicking motile
                      biological cells, such as keratocytes and neutrophils. When
                      interacting with walls or with interfaces between different
                      substrates, the internal structure of a flexocyte
                      reorganizes, resulting in a preferred angle of reflection or
                      deflection, respectively. We predict a correlation between
                      motility patterns, shapes, characteristics of the internal
                      forces, and the response to micropatterned substrates and
                      external stimuli. We propose that engineered flexocytes with
                      desired mechanosensitive capabilities enable the
                      construction of soft-matter microbots.},
      cin          = {ICS-2 / JARA-HPC},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ICS-2-20110106 / $I:(DE-82)080012_20140620$},
      pnm          = {553 - Physical Basis of Diseases (POF3-553) / Hydrodynamics
                      of Active Biological Systems $(jiff26_20110501)$},
      pid          = {G:(DE-HGF)POF3-553 / $G:(DE-Juel1)jiff26_20110501$},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000513663400023},
      doi          = {10.1088/1367-2630/ab5c70},
      url          = {https://juser.fz-juelich.de/record/867555},
}