TY  - JOUR
AU  - Contente, Martina Letizia
AU  - Dall’Oglio, Federica
AU  - Annunziata, Francesca
AU  - Molinari, Francesco
AU  - Rabuffetti, Marco
AU  - Romano, Diego
AU  - Tamborini, Lucia
AU  - Rother, Dörte
AU  - Pinto, Andrea
TI  - Stereoselective Reduction of Prochiral Cyclic 1,3-Diketones Using Different Biocatalysts
JO  - Catalysis letters
VL  - 150
SN  - 1572-879X
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V
M1  - FZJ-2019-06263
SP  - 1176-1185
PY  - 2020
AB  - We have developed biocatalytic methods for the stereoselective reduction of cyclic prochiral 1,3-diketones for the production of optically active β-hydroxyketones and/or 1,3-diols. The recombinant ketoreductase KRED1-Pglu (formulated as purified catalyst) and whole cells of wild type Escherichia coli DE3 Star were used as biocatalysts, displaying different and sometimes complementary stereoselectivity, thus allowing the preparation of stereochemically pure β-hydroxyketones (12–66% isolated yields, > 99% e.e.) and 1,3-diols (40–60% isolated yields, > 99% e.e.).
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000495029200001
DO  - DOI:10.1007/s10562-019-03015-y
UR  - https://juser.fz-juelich.de/record/867642
ER  -