Journal Article

FZJ-2019-06263

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Stereoselective Reduction of Prochiral Cyclic 1,3-Diketones Using Different Biocatalysts

Contente, M. L. ; Dall’Oglio, F. ; Annunziata, F. ; Molinari, F. ; Rabuffetti, M. ; Romano, D. ; Tamborini, L. ; Rother, D.FZJ* ; Pinto, A. (Corresponding author)

2020
Springer Science + Business Media B.V Dordrecht [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/24950  doi:10.1007/s10562-019-03015-y

Abstract: We have developed biocatalytic methods for the stereoselective reduction of cyclic prochiral 1,3-diketones for the production of optically active β-hydroxyketones and/or 1,3-diols. The recombinant ketoreductase KRED1-Pglu (formulated as purified catalyst) and whole cells of wild type Escherichia coli DE3 Star were used as biocatalysts, displaying different and sometimes complementary stereoselectivity, thus allowing the preparation of stereochemically pure β-hydroxyketones (12–66% isolated yields, > 99% e.e.) and 1,3-diols (40–60% isolated yields, > 99% e.e.).

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Contributing Institute(s):

1. Biotechnologie (IBG-1)

Research Program(s):

1. 581 - Biotechnology (POF3-581) (POF3-581)

Appears in the scientific report 2020

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Database coverage:
; ; Clarivate Analytics Master Journal List ; Current Contents - Engineering, Computing and Technology ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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