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000874906 1001_ $$0P:(DE-Juel1)177870$$aBeckers, Maximilian$$b0$$eCorresponding author
000874906 245__ $$aConfidence maps: statistical inference of cryo-EM maps
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000874906 520__ $$aConfidence maps provide complementary information for interpreting cryo-EM densities as they indicate statistical significance with respect to background noise. They can be thresholded by specifying the expected false-discovery rate (FDR), and the displayed volume shows the parts of the map that have the corresponding level of significance. Here, the basic statistical concepts of confidence maps are reviewed and practical guidance is provided for their interpretation and usage inside the CCP-EM suite. Limitations of the approach are discussed and extensions towards other error criteria such as the family-wise error rate are presented. The observed map features can be rendered at a common isosurface threshold, which is particularly beneficial for the interpretation of weak and noisy densities. In the current article, a practical guide is provided to the recommended usage of confidence maps.
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000874906 7001_ $$00000-0002-4883-1546$$aPalmer, Colin M.$$b1
000874906 7001_ $$0P:(DE-Juel1)173949$$aSachse, Carsten$$b2$$eCorresponding author
000874906 773__ $$0PERI:(DE-600)2020492-9$$a10.1107/S2059798320002995$$gVol. 76, no. 4$$n4$$p1-8$$tActa crystallographica / D Biological crystallography online Section D$$v76$$x2059-7983$$y2020
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