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@ARTICLE{Beckers:874906,
      author       = {Beckers, Maximilian and Palmer, Colin M. and Sachse,
                      Carsten},
      title        = {{C}onfidence maps: statistical inference of cryo-{EM} maps},
      journal      = {Acta crystallographica / D Biological crystallography
                      online Section D},
      volume       = {76},
      number       = {4},
      issn         = {2059-7983},
      address      = {Oxford},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2020-01694},
      pages        = {1-8},
      year         = {2020},
      abstract     = {Confidence maps provide complementary information for
                      interpreting cryo-EM densities as they indicate statistical
                      significance with respect to background noise. They can be
                      thresholded by specifying the expected false-discovery rate
                      (FDR), and the displayed volume shows the parts of the map
                      that have the corresponding level of significance. Here, the
                      basic statistical concepts of confidence maps are reviewed
                      and practical guidance is provided for their interpretation
                      and usage inside the CCP-EM suite. Limitations of the
                      approach are discussed and extensions towards other error
                      criteria such as the family-wise error rate are presented.
                      The observed map features can be rendered at a common
                      isosurface threshold, which is particularly beneficial for
                      the interpretation of weak and noisy densities. In the
                      current article, a practical guide is provided to the
                      recommended usage of confidence maps.},
      cin          = {ER-C-3},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ER-C-3-20170113},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32254057},
      UT           = {WOS:000524555300004},
      doi          = {10.1107/S2059798320002995},
      url          = {https://juser.fz-juelich.de/record/874906},
}