TY  - JOUR
AU  - Vliegenthart, Gerard A.
AU  - Ravichandran, Arvind
AU  - Ripoll, Marisol
AU  - Auth, Thorsten
AU  - Gompper, Gerhard
TI  - Filamentous active matter: Band formation, bending, buckling, and defects
JO  - Science advances
VL  - 6
IS  - 30
SN  - 2375-2548
CY  - Washington, DC [u.a.]
PB  - Assoc.
M1  - FZJ-2020-02037
SP  - eaaw9975
PY  - 2020
AB  - Motor proteins drive persistent motion and self-organization of cytoskeletal filaments. However, state-of-the-art microscopy techniques and continuum modeling approaches focus on large length and time scales. Here, we perform component-based computer simulations of polar filaments and molecular motors linking microscopic interactions and activity to self-organization and dynamics from the filament level up to the mesoscopic domain level. Dynamic filament cross-linking and sliding and excluded-volume interactions promote formation of bundles at small densities and of active polar nematics at high densities. A buckling-type instability sets the size of polar domains and the density of topological defects. We predict a universal scaling of the active diffusion coefficient and the domain size with activity, and its dependence on parameters like motor concentration and filament persistence length. Our results provide a microscopic understanding of cytoplasmic streaming in cells and help to develop design strategies for novel engineered active materials.
LB  - PUB:(DE-HGF)16
C6  - pmid:32832652
UR  - <Go to ISI:>//WOS:000552228100001
DO  - DOI:10.1126/sciadv.aaw9975
UR  - https://juser.fz-juelich.de/record/875442
ER  -