TY  - JOUR
AU  - Choi, Seung-Min
AU  - Jeong, Jae-Chan
AU  - Kim, Jinsun
AU  - Lim, Eul-Gyoon
AU  - Kim, Chang-beom
AU  - Park, Sang-Jin
AU  - Song, Dae-Yong
AU  - Krause, Hans-Joachim
AU  - Hong, Hyobong
AU  - Kweon, In So
TI  - A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics
JO  - Scientific reports
VL  - 10
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - FZJ-2020-02576
SP  - 11833
PY  - 2020
AB  - The magnetic particle imaging (MPI) is a technology that can image the concentrations of the superparamagnetic iron oxide nanoparticles (SPIONs) which can be used in biomedical diagnostics and therapeutics as non-radioactive tracers. We proposed a point-of-care testing MPI system (PoCT- MPI) that can be used for preclinical use for imaging small rodents (mice) injected with SPIONs not only in laboratories, but also at emergency sites far from laboratories. In particular, we applied a frequency mixing magnetic detection method to the PoCT-MPI, and proposed a hybrid field free line generator to reduce the power consumption, size and weight of the system. The PoCT-MPI is 20 × 33 × 45 cm³ in size and weighs less than 100 kg. It can image a three-dimensional distribution of SPIONs injected into a biosample with less than 120 Wh of power consumption. Its detection limit is 0.13μL , 10 mg/mL, 1.3μg (Fe).
LB  - PUB:(DE-HGF)16
C6  - pmid:32678265
UR  - <Go to ISI:>//WOS:000550057200146
DO  - DOI:10.1038/s41598-020-68864-9
UR  - https://juser.fz-juelich.de/record/878002
ER  -