Journal Article

FZJ-2020-02576

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics

Choi, S.-M. (Corresponding author) ; Jeong, J.-C. ; Kim, J. ; Lim, E.-G. ; Kim, C.-b. ; Park, S.-J. ; Song, D.-Y. ; Krause, H.-J.FZJ* ; Hong, H. ; Kweon, I. S.

2020
Macmillan Publishers Limited, part of Springer Nature [London]

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Please use a persistent id in citations: http://hdl.handle.net/2128/25739  doi:10.1038/s41598-020-68864-9

Abstract: The magnetic particle imaging (MPI) is a technology that can image the concentrations of the superparamagnetic iron oxide nanoparticles (SPIONs) which can be used in biomedical diagnostics and therapeutics as non-radioactive tracers. We proposed a point-of-care testing MPI system (PoCT- MPI) that can be used for preclinical use for imaging small rodents (mice) injected with SPIONs not only in laboratories, but also at emergency sites far from laboratories. In particular, we applied a frequency mixing magnetic detection method to the PoCT-MPI, and proposed a hybrid field free line generator to reduce the power consumption, size and weight of the system. The PoCT-MPI is 20 × 33 × 45 cm³ in size and weighs less than 100 kg. It can image a three-dimensional distribution of SPIONs injected into a biosample with less than 120 Wh of power consumption. Its detection limit is 0.13μL , 10 mg/mL, 1.3μg (Fe).

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Contributing Institute(s):

1. Bioelektronik (IBI-3)

Research Program(s):

1. 523 - Controlling Configuration-Based Phenomena (POF3-523) (POF3-523)

Appears in the scientific report 2020

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