Journal Article

FZJ-2020-02828

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Bimetallic silver–platinum nanoparticles with combined osteo-promotive and antimicrobial activity

Breisch, M. (Corresponding author) ; Grasmik, V. ; Loza, K. ; Pappert, K. ; Rostek, A. ; Ziegler, N. ; Ludwig, A. ; Heggen, M.FZJ* ; Epple, M.Extern* ; Tiller, J. C. ; Schildhauer, T. A. ; Köller, M. ; Sengstock, C.

2019
IOP Publ. Bristol

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Please use a persistent id in citations: doi:10.1088/1361-6528/ab172b

Abstract: Bimetallic alloyed silver–platinum nanoparticles (AgPt NP) with different metal composition from Ag10Pt90 to Ag90Pt10 in steps of 20 mol% were synthesized. The biological effects of AgPt NP, including cellular uptake, cell viability, osteogenic differentiation and osteoclastogenesis as well as the antimicrobial activity towards Staphylococcus aureus and Escherichia coli were analyzed in comparison to pure Ag NP and pure Pt NP. The uptake of NP into human mesenchymal stem cells was confirmed by cross-sectional focused-ion beam preparation and observation by scanning and transmission electron microscopy in combination with energy-dispersive x-ray analysis. Lower cytotoxicity and antimicrobial activity were observed for AgPt NP compared to pure Ag NP. Thus, an enhanced Ag ion release due to a possible sacrificial anode effect was not achieved. Nevertheless, a Ag content of at least 50 mol% was sufficient to induce bactericidal effects against both Staphylococcus aureus and Escherichia coli. In addition, a Pt-related (≥50 mol% Pt) osteo-promotive activity on human mesenchymal stem cells was observed by enhanced cell calcification and alkaline phosphatase activity. In contrast, the osteoclastogenesis of rat primary precursor osteoclasts was inhibited. In summary, these results demonstrate a combinatory osteo-promotive and antimicrobial activity of bimetallic Ag50Pt50 NP.

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Contributing Institute(s):

1. Physik Nanoskaliger Systeme (ER-C-1)

Research Program(s):

1. 143 - Controlling Configuration-Based Phenomena (POF3-143) (POF3-143)
2. DFG project 286659497 - Bimetallische Nanopartikel der Platinmetalle (Ru, Rh, Pd, Os, Ir, Pt) und des Silbers: Synthese, Mikrostruktur und biologische Wirkung (286659497) (286659497)

Appears in the scientific report 2020

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Engineering, Computing and Technology ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; National-Konsortium ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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