TY  - JOUR
AU  - Breisch, Marina
AU  - Grasmik, Viktoria
AU  - Loza, Kateryna
AU  - Pappert, Kevin
AU  - Rostek, Alexander
AU  - Ziegler, Nadine
AU  - Ludwig, Alfred
AU  - Heggen, Marc
AU  - Epple, Matthias
AU  - Tiller, Jörg C
AU  - Schildhauer, Thomas A
AU  - Köller, Manfred
AU  - Sengstock, Christina
TI  - Bimetallic silver–platinum nanoparticles with combined osteo-promotive and antimicrobial activity
JO  - Nanotechnology
VL  - 30
IS  - 30
SN  - 1361-6528
CY  - Bristol
PB  - IOP Publ.
M1  - FZJ-2020-02828
SP  - 305101 -
PY  - 2019
AB  - Bimetallic alloyed silver–platinum nanoparticles (AgPt NP) with different metal composition from Ag10Pt90 to Ag90Pt10 in steps of 20 mol% were synthesized. The biological effects of AgPt NP, including cellular uptake, cell viability, osteogenic differentiation and osteoclastogenesis as well as the antimicrobial activity towards Staphylococcus aureus and Escherichia coli were analyzed in comparison to pure Ag NP and pure Pt NP. The uptake of NP into human mesenchymal stem cells was confirmed by cross-sectional focused-ion beam preparation and observation by scanning and transmission electron microscopy in combination with energy-dispersive x-ray analysis. Lower cytotoxicity and antimicrobial activity were observed for AgPt NP compared to pure Ag NP. Thus, an enhanced Ag ion release due to a possible sacrificial anode effect was not achieved. Nevertheless, a Ag content of at least 50 mol% was sufficient to induce bactericidal effects against both Staphylococcus aureus and Escherichia coli. In addition, a Pt-related (≥50 mol% Pt) osteo-promotive activity on human mesenchymal stem cells was observed by enhanced cell calcification and alkaline phosphatase activity. In contrast, the osteoclastogenesis of rat primary precursor osteoclasts was inhibited. In summary, these results demonstrate a combinatory osteo-promotive and antimicrobial activity of bimetallic Ag50Pt50 NP.
LB  - PUB:(DE-HGF)16
C6  - pmid:30959494
UR  - <Go to ISI:>//WOS:000466803300001
DO  - DOI:10.1088/1361-6528/ab172b
UR  - https://juser.fz-juelich.de/record/878392
ER  -