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@ARTICLE{Breisch:878392,
      author       = {Breisch, Marina and Grasmik, Viktoria and Loza, Kateryna
                      and Pappert, Kevin and Rostek, Alexander and Ziegler, Nadine
                      and Ludwig, Alfred and Heggen, Marc and Epple, Matthias and
                      Tiller, Jörg C and Schildhauer, Thomas A and Köller,
                      Manfred and Sengstock, Christina},
      title        = {{B}imetallic silver–platinum nanoparticles with combined
                      osteo-promotive and antimicrobial activity},
      journal      = {Nanotechnology},
      volume       = {30},
      number       = {30},
      issn         = {1361-6528},
      address      = {Bristol},
      publisher    = {IOP Publ.},
      reportid     = {FZJ-2020-02828},
      pages        = {305101 -},
      year         = {2019},
      abstract     = {Bimetallic alloyed silver–platinum nanoparticles (AgPt
                      NP) with different metal composition from Ag10Pt90 to
                      Ag90Pt10 in steps of 20 $mol\%$ were synthesized. The
                      biological effects of AgPt NP, including cellular uptake,
                      cell viability, osteogenic differentiation and
                      osteoclastogenesis as well as the antimicrobial activity
                      towards Staphylococcus aureus and Escherichia coli were
                      analyzed in comparison to pure Ag NP and pure Pt NP. The
                      uptake of NP into human mesenchymal stem cells was confirmed
                      by cross-sectional focused-ion beam preparation and
                      observation by scanning and transmission electron microscopy
                      in combination with energy-dispersive x-ray analysis. Lower
                      cytotoxicity and antimicrobial activity were observed for
                      AgPt NP compared to pure Ag NP. Thus, an enhanced Ag ion
                      release due to a possible sacrificial anode effect was not
                      achieved. Nevertheless, a Ag content of at least 50 $mol\%$
                      was sufficient to induce bactericidal effects against both
                      Staphylococcus aureus and Escherichia coli. In addition, a
                      Pt-related (≥50 $mol\%$ Pt) osteo-promotive activity on
                      human mesenchymal stem cells was observed by enhanced cell
                      calcification and alkaline phosphatase activity. In
                      contrast, the osteoclastogenesis of rat primary precursor
                      osteoclasts was inhibited. In summary, these results
                      demonstrate a combinatory osteo-promotive and antimicrobial
                      activity of bimetallic Ag50Pt50 NP.},
      cin          = {ER-C-1},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ER-C-1-20170209},
      pnm          = {143 - Controlling Configuration-Based Phenomena (POF3-143)
                      / DFG project 286659497 - Bimetallische Nanopartikel der
                      Platinmetalle (Ru, Rh, Pd, Os, Ir, Pt) und des Silbers:
                      Synthese, Mikrostruktur und biologische Wirkung (286659497)},
      pid          = {G:(DE-HGF)POF3-143 / G:(GEPRIS)286659497},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30959494},
      UT           = {WOS:000466803300001},
      doi          = {10.1088/1361-6528/ab172b},
      url          = {https://juser.fz-juelich.de/record/878392},
}