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@ARTICLE{Sonnewald:878722,
      author       = {Sonnewald, Uwe and Fernie, Alisdair R. and Gruissem,
                      Wilhelm and Schläpfer, Pascal and Anjanappa, Ravi B. and
                      Chang, Shu‐Heng and Ludewig, Frank and Rascher, Uwe and
                      Muller, Onno and Doorn, Anna M. and Rabbi, Ismail Y. and
                      Zierer, Wolfgang},
      title        = {{T}he {C}assava {S}ource–{S}ink project: opportunities
                      and challenges for crop improvement by metabolic
                      engineering},
      journal      = {The plant journal},
      volume       = {103},
      number       = {5},
      issn         = {1365-313X},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2020-03022},
      pages        = {1655 - 1665},
      year         = {2020},
      abstract     = {Cassava (Manihot esculenta Crantz) is one of the important
                      staple foods in Sub‐Saharan Africa. It produces starchy
                      storage roots that provide food and income for several
                      hundred million people, mainly in tropical agriculture
                      zones. Increasing cassava storage root and starch yield is
                      one of the major breeding targets with respect to securing
                      the future food supply for the growing population of
                      Sub‐Saharan Africa. The Cassava Source–Sink (CASS)
                      project aims to increase cassava storage root and starch
                      yield by strategically integrating approaches from different
                      disciplines. We present our perspective and progress on
                      cassava as an applied research organism and provide insight
                      into the CASS strategy, which can serve as a blueprint for
                      the improvement of other root and tuber crops. Extensive
                      profiling of different field‐grown cassava genotypes
                      generates information for leaf, phloem, and root metabolic
                      and physiological processes that are relevant for
                      biotechnological improvements. A multi‐national pipeline
                      for genetic engineering of cassava plants covers all steps
                      from gene discovery, cloning, transformation, molecular and
                      biochemical characterization, confined field trials, and
                      phenotyping of the seasonal dynamics of shoot traits under
                      field conditions. Together, the CASS project generates
                      comprehensive data to facilitate conventional breeding
                      strategies for high‐yielding cassava genotypes. It also
                      builds the foundation for genome‐scale metabolic modelling
                      aiming to predict targets and bottlenecks in metabolic
                      pathways. This information is used to engineer cassava
                      genotypes with improved source–sink relations and
                      increased yield potential.},
      cin          = {IBG-2},
      ddc          = {580},
      cid          = {I:(DE-Juel1)IBG-2-20101118},
      pnm          = {582 - Plant Science (POF3-582)},
      pid          = {G:(DE-HGF)POF3-582},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32502321},
      UT           = {WOS:000543137600001},
      doi          = {10.1111/tpj.14865},
      url          = {https://juser.fz-juelich.de/record/878722},
}