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000884747 1001_ $$00000-0002-2791-2400$$aHochstetter, Axel$$b0
000884747 245__ $$aDeterministic Lateral Displacement: Challenges and Perspectives
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000884747 520__ $$aThe advent of microfluidics in the 1990s promised a revolution in multiple industries from healthcare to chemical processing. Deterministic lateral displacement (DLD) is a continuous-flow microfluidic particle separation method discovered in 2004 that has been applied successfully and widely to the separation of blood cells, yeast, spores, bacteria, viruses, DNA, droplets, and more. Deterministic lateral displacement is conceptually simple and can deliver consistent performance over a wide range of flow rates and particle concentrations. Despite wide use and in-depth study, DLD has not yet been fully elucidated or optimized, with different approaches to the same problem yielding varying results. We endeavor here to provide up-to-date expert opinion on the state-of-art and current fundamental, practical, and commercial challenges with DLD as well as describe experimental and modeling opportunities. Because these challenges and opportunities arise from constraints on hydrodynamics, fabrication, and operation at the micro- and nanoscale, we expect this Perspective to serve as a guide for the broader micro- and nanofluidic community to identify and to address open questions in the field.
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000884747 7001_ $$0P:(DE-HGF)0$$aVernekar, Rohan$$b1
000884747 7001_ $$0P:(DE-HGF)0$$aAustin, Robert H.$$b2
000884747 7001_ $$00000-0002-7678-2518$$aBecker, Holger$$b3
000884747 7001_ $$0P:(DE-HGF)0$$aBeech, Jason P.$$b4
000884747 7001_ $$0P:(DE-Juel1)140336$$aFedosov, Dmitry A.$$b5
000884747 7001_ $$0P:(DE-Juel1)130665$$aGompper, Gerhard$$b6
000884747 7001_ $$0P:(DE-HGF)0$$aKim, Sung-Cheol$$b7
000884747 7001_ $$00000-0002-3530-0850$$aSmith, Joshua T.$$b8
000884747 7001_ $$0P:(DE-HGF)0$$aStolovitzky, Gustavo$$b9
000884747 7001_ $$00000-0002-3695-6886$$aTegenfeldt, Jonas O.$$b10
000884747 7001_ $$0P:(DE-HGF)0$$aWunsch, Benjamin H.$$b11
000884747 7001_ $$0P:(DE-HGF)0$$aZeming, Kerwin K.$$b12
000884747 7001_ $$0P:(DE-HGF)0$$aKrüger, Timm$$b13
000884747 7001_ $$00000-0001-8239-5568$$aInglis, David W.$$b14$$eCorresponding author
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000884747 8564_ $$uhttps://juser.fz-juelich.de/record/884747/files/Hochstetter_ACSN_2020.pdf$$yPublished on 2020-08-26. Available in OpenAccess from 2021-08-26.
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