Journal Article

FZJ-2020-03236

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Deterministic Lateral Displacement: Challenges and Perspectives

Hochstetter, A. ; Vernekar, R. ; Austin, R. H. ; Becker, H. ; Beech, J. P. ; Fedosov, D. A.FZJ* ; Gompper, G.FZJ* ; Kim, S.-C. ; Smith, J. T. ; Stolovitzky, G. ; Tegenfeldt, J. O. ; Wunsch, B. H. ; Zeming, K. K. ; Krüger, T. ; Inglis, D. W. (Corresponding author)

2020
Soc. Washington, DC

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Please use a persistent id in citations: http://hdl.handle.net/2128/25734  doi:10.1021/acsnano.0c05186

Abstract: The advent of microfluidics in the 1990s promised a revolution in multiple industries from healthcare to chemical processing. Deterministic lateral displacement (DLD) is a continuous-flow microfluidic particle separation method discovered in 2004 that has been applied successfully and widely to the separation of blood cells, yeast, spores, bacteria, viruses, DNA, droplets, and more. Deterministic lateral displacement is conceptually simple and can deliver consistent performance over a wide range of flow rates and particle concentrations. Despite wide use and in-depth study, DLD has not yet been fully elucidated or optimized, with different approaches to the same problem yielding varying results. We endeavor here to provide up-to-date expert opinion on the state-of-art and current fundamental, practical, and commercial challenges with DLD as well as describe experimental and modeling opportunities. Because these challenges and opportunities arise from constraints on hydrodynamics, fabrication, and operation at the micro- and nanoscale, we expect this Perspective to serve as a guide for the broader micro- and nanofluidic community to identify and to address open questions in the field.

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Contributing Institute(s):

1. Theoretische Physik der Lebenden Materie (IBI-5)

Research Program(s):

1. 552 - Engineering Cell Function (POF3-552) (POF3-552)

Appears in the scientific report 2020

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Database coverage:
; ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; Essential Science Indicators ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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