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@ARTICLE{Hochstetter:884747,
      author       = {Hochstetter, Axel and Vernekar, Rohan and Austin, Robert H.
                      and Becker, Holger and Beech, Jason P. and Fedosov, Dmitry
                      A. and Gompper, Gerhard and Kim, Sung-Cheol and Smith,
                      Joshua T. and Stolovitzky, Gustavo and Tegenfeldt, Jonas O.
                      and Wunsch, Benjamin H. and Zeming, Kerwin K. and Krüger,
                      Timm and Inglis, David W.},
      title        = {{D}eterministic {L}ateral {D}isplacement: {C}hallenges and
                      {P}erspectives},
      journal      = {ACS nano},
      volume       = {14},
      number       = {9},
      issn         = {1936-086X},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {FZJ-2020-03236},
      pages        = {10784 - 10795},
      year         = {2020},
      abstract     = {The advent of microfluidics in the 1990s promised a
                      revolution in multiple industries from healthcare to
                      chemical processing. Deterministic lateral displacement
                      (DLD) is a continuous-flow microfluidic particle separation
                      method discovered in 2004 that has been applied successfully
                      and widely to the separation of blood cells, yeast, spores,
                      bacteria, viruses, DNA, droplets, and more. Deterministic
                      lateral displacement is conceptually simple and can deliver
                      consistent performance over a wide range of flow rates and
                      particle concentrations. Despite wide use and in-depth
                      study, DLD has not yet been fully elucidated or optimized,
                      with different approaches to the same problem yielding
                      varying results. We endeavor here to provide up-to-date
                      expert opinion on the state-of-art and current fundamental,
                      practical, and commercial challenges with DLD as well as
                      describe experimental and modeling opportunities. Because
                      these challenges and opportunities arise from constraints on
                      hydrodynamics, fabrication, and operation at the micro- and
                      nanoscale, we expect this Perspective to serve as a guide
                      for the broader micro- and nanofluidic community to identify
                      and to address open questions in the field.},
      cin          = {IBI-5},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBI-5-20200312},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32844655},
      UT           = {WOS:000615914200002},
      doi          = {10.1021/acsnano.0c05186},
      url          = {https://juser.fz-juelich.de/record/884747},
}