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@ARTICLE{Hensel:885429,
      author       = {Hensel, Lukas and Tscherpel, Caroline and Freytag, Jana and
                      Ritter, Stella and Rehme, Anne K and Volz, Lukas J and
                      Eickhoff, Simon B and Fink, Gereon R and Grefkes, Christian},
      title        = {{C}onnectivity-{R}elated {R}oles of {C}ontralesional
                      {B}rain {R}egions for {M}otor {P}erformance {E}arly after
                      {S}troke},
      journal      = {Cerebral cortex},
      volume       = {31},
      number       = {2},
      issn         = {1460-2199},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2020-03826},
      pages        = {993–1007},
      year         = {2021},
      abstract     = {Hemiparesis after stroke is associated with increased
                      neural activity not only in the lesioned but also in the
                      contralesional hemisphere. While most studies have focused
                      on the role of contralesional primary motor cortex (M1)
                      activity for motor performance, data on other areas within
                      the unaffected hemisphere are scarce, especially early after
                      stroke. We here combined functional magnetic resonance
                      imaging (fMRI) and transcranial magnetic stimulation (TMS)
                      to elucidate the contribution of contralesional M1, dorsal
                      premotor cortex (dPMC), and anterior intraparietal sulcus
                      (aIPS) for the stroke-affected hand within the first 10 days
                      after stroke. We used "online" TMS to interfere with neural
                      activity at subject-specific fMRI coordinates while
                      recording 3D movement kinematics. Interfering with aIPS
                      activity improved tapping performance in patients, but not
                      healthy controls, suggesting a maladaptive role of this
                      region early poststroke. Analyzing effective connectivity
                      parameters using a Lasso prediction model revealed that
                      behavioral TMS effects were predicted by the coupling of the
                      stimulated aIPS with dPMC and ipsilesional M1. In
                      conclusion, we found a strong link between patterns of
                      frontoparietal connectivity and TMS effects, indicating a
                      detrimental influence of the contralesional aIPS on motor
                      performance early after stroke.Keywords: DCM; diaschisis;
                      kinematics; motor network; recovery.},
      cin          = {INM-7 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-3-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571) / 5252 - Brain
                      Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF3-571 / G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32995880},
      UT           = {WOS:000646868100019},
      doi          = {10.1093/cercor/bhaa270},
      url          = {https://juser.fz-juelich.de/record/885429},
}