Journal Article

FZJ-2020-03826

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Connectivity-Related Roles of Contralesional Brain Regions for Motor Performance Early after Stroke

Hensel, L. ; Tscherpel, C.FZJ* ; Freytag, J. ; Ritter, S. ; Rehme, A. K. ; Volz, L. J. ; Eickhoff, S. B.FZJ* ; Fink, G. R.FZJ* ; Grefkes, C. (Corresponding author)FZJ*

2021
Oxford Univ. Press Oxford

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Please use a persistent id in citations: http://hdl.handle.net/2128/26764  doi:10.1093/cercor/bhaa270

Abstract: Hemiparesis after stroke is associated with increased neural activity not only in the lesioned but also in the contralesional hemisphere. While most studies have focused on the role of contralesional primary motor cortex (M1) activity for motor performance, data on other areas within the unaffected hemisphere are scarce, especially early after stroke. We here combined functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) to elucidate the contribution of contralesional M1, dorsal premotor cortex (dPMC), and anterior intraparietal sulcus (aIPS) for the stroke-affected hand within the first 10 days after stroke. We used "online" TMS to interfere with neural activity at subject-specific fMRI coordinates while recording 3D movement kinematics. Interfering with aIPS activity improved tapping performance in patients, but not healthy controls, suggesting a maladaptive role of this region early poststroke. Analyzing effective connectivity parameters using a Lasso prediction model revealed that behavioral TMS effects were predicted by the coupling of the stimulated aIPS with dPMC and ipsilesional M1. In conclusion, we found a strong link between patterns of frontoparietal connectivity and TMS effects, indicating a detrimental influence of the contralesional aIPS on motor performance early after stroke.Keywords: DCM; diaschisis; kinematics; motor network; recovery.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)
2. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 571 - Connectivity and Activity (POF3-571) (POF3-571)
2. 5252 - Brain Dysfunction and Plasticity (POF4-525) (POF4-525)

Appears in the scientific report 2021

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Database coverage:
; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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