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000885673 1001_ $$00000-0002-8464-7324$$aCostantini, Irene$$b0$$eCorresponding author
000885673 245__ $$aMAGIC: A label-free fluorescence method for 3D high-resolution reconstruction of myelinated fibers in large volumes
000885673 260__ $$c2020
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000885673 520__ $$aAnalyzing the structure of neuronal fibers with single axon resolution, in large volumes, remains an unresolved challenge in connectomics. Here, we propose MAGIC (Myelin Autofluorescence imaging by Glycerol Induced Contrast enhancement), a simple tissue preparation method to perform label-free fluorescence imaging of myelinated fibers. We demonstrate its broad applicability by performing mesoscopic reconstruction at sub-micron resolution of mouse, rat, monkey, and human brain samples and by quantifying the different fiber organization in Control and Reeler mouse’s hippocampal sections.
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000885673 536__ $$0G:(EU-Grant)945539$$aHBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539)$$c945539$$x2
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000885673 7001_ $$0P:(DE-HGF)0$$aBaria, Enrico$$b1
000885673 7001_ $$0P:(DE-HGF)0$$aSorelli, Michele$$b2
000885673 7001_ $$0P:(DE-Juel1)169807$$aMatuschke, Felix$$b3
000885673 7001_ $$0P:(DE-HGF)0$$aGiardini, Francesco$$b4
000885673 7001_ $$0P:(DE-Juel1)161196$$aMenzel, Miriam$$b5
000885673 7001_ $$0P:(DE-HGF)0$$aMazzamuto, Giacomo$$b6
000885673 7001_ $$0P:(DE-HGF)0$$aSilvestri, Ludovico$$b7
000885673 7001_ $$0P:(DE-HGF)0$$aCicchi, Riccardo$$b8
000885673 7001_ $$0P:(DE-Juel1)131631$$aAmunts, Katrin$$b9
000885673 7001_ $$0P:(DE-Juel1)131632$$aAxer, Markus$$b10
000885673 7001_ $$0P:(DE-HGF)0$$aPavone, Francesco Saverio$$b11
000885673 773__ $$a10.1101/2020.07.28.225011
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