Hauptseite > Publikationsdatenbank > MAGIC: A label-free fluorescence method for 3D high-resolution reconstruction of myelinated fibers in large volumes > print

001     885673
005     20210130010451.0
024 7 _ |a 10.1101/2020.07.28.225011
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037 _ _ |a FZJ-2020-04004
100 1 _ |a Costantini, Irene
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245 _ _ |a MAGIC: A label-free fluorescence method for 3D high-resolution reconstruction of myelinated fibers in large volumes
260 _ _ |c 2020
336 7 _ |a Preprint
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520 _ _ |a Analyzing the structure of neuronal fibers with single axon resolution, in large volumes, remains an unresolved challenge in connectomics. Here, we propose MAGIC (Myelin Autofluorescence imaging by Glycerol Induced Contrast enhancement), a simple tissue preparation method to perform label-free fluorescence imaging of myelinated fibers. We demonstrate its broad applicability by performing mesoscopic reconstruction at sub-micron resolution of mouse, rat, monkey, and human brain samples and by quantifying the different fiber organization in Control and Reeler mouse’s hippocampal sections.
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536 _ _ |a HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907)
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536 _ _ |a HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539)
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700 1 _ |a Baria, Enrico
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700 1 _ |a Sorelli, Michele
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700 1 _ |a Matuschke, Felix
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700 1 _ |a Giardini, Francesco
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700 1 _ |a Menzel, Miriam
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700 1 _ |a Mazzamuto, Giacomo
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700 1 _ |a Silvestri, Ludovico
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700 1 _ |a Cicchi, Riccardo
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700 1 _ |a Amunts, Katrin
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700 1 _ |a Axer, Markus
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700 1 _ |a Pavone, Francesco Saverio
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773 _ _ |a 10.1101/2020.07.28.225011
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