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000887675 1001_ $$0P:(DE-HGF)0$$aChételat, Gaël$$b0$$eCorresponding author
000887675 245__ $$aAmyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias
000887675 260__ $$aLondon$$bLancet Publ. Group$$c2020
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000887675 520__ $$aVarious biomarkers are available to support the diagnosis of neurodegenerative diseases in clinical and research settings. Among the molecular imaging biomarkers, amyloid-PET, which assesses brain amyloid deposition, and 18F-fluorodeoxyglucose (18F-FDG) PET, which assesses glucose metabolism, provide valuable and complementary information. However, uncertainty remains regarding the optimal timepoint, combination, and an order in which these PET biomarkers should be used in diagnostic evaluations because conclusive evidence is missing. Following an expert panel discussion, we reached an agreement on the specific use of the individual biomarkers, based on available evidence and clinical expertise. We propose a diagnostic algorithm with optimal timepoints for these PET biomarkers, also taking into account evidence from other biomarkers, for early and differential diagnosis of neurodegenerative diseases that can lead to dementia. We propose three main diagnostic pathways with distinct biomarker sequences, in which amyloid-PET and 18F-FDG-PET are placed at different positions in the order of diagnostic evaluations, depending on clinical presentation. We hope that this algorithm can support diagnostic decision making in specialist clinical settings with access to these biomarkers and might stimulate further research towards optimal diagnostic strategies.
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000887675 7001_ $$0P:(DE-HGF)0$$aArbizu, Javier$$b1
000887675 7001_ $$0P:(DE-HGF)0$$aBarthel, Henryk$$b2
000887675 7001_ $$0P:(DE-HGF)0$$aGaribotto, Valentina$$b3
000887675 7001_ $$0P:(DE-HGF)0$$aLaw, Ian$$b4
000887675 7001_ $$0P:(DE-HGF)0$$aMorbelli, Silvia$$b5
000887675 7001_ $$0P:(DE-HGF)0$$avan de Giessen, Elsmarieke$$b6
000887675 7001_ $$0P:(DE-HGF)0$$aAgosta, Federica$$b7
000887675 7001_ $$0P:(DE-HGF)0$$aBarkhof, Frederik$$b8
000887675 7001_ $$0P:(DE-HGF)0$$aBrooks, David J$$b9
000887675 7001_ $$0P:(DE-HGF)0$$aCarrillo, Maria C$$b10
000887675 7001_ $$0P:(DE-HGF)0$$aDubois, Bruno$$b11
000887675 7001_ $$0P:(DE-HGF)0$$aFjell, Anders M$$b12
000887675 7001_ $$0P:(DE-HGF)0$$aFrisoni, Giovanni B$$b13
000887675 7001_ $$0P:(DE-HGF)0$$aHansson, Oskar$$b14
000887675 7001_ $$0P:(DE-HGF)0$$aHerholz, Karl$$b15
000887675 7001_ $$0P:(DE-HGF)0$$aHutton, Brian F$$b16
000887675 7001_ $$0P:(DE-HGF)0$$aJack, Clifford R$$b17
000887675 7001_ $$0P:(DE-HGF)0$$aLammertsma, Adriaan A$$b18
000887675 7001_ $$0P:(DE-HGF)0$$aLandau, Susan M$$b19
000887675 7001_ $$0P:(DE-HGF)0$$aMinoshima, Satoshi$$b20
000887675 7001_ $$0P:(DE-HGF)0$$aNobili, Flavio$$b21
000887675 7001_ $$0P:(DE-HGF)0$$aNordberg, Agneta$$b22
000887675 7001_ $$0P:(DE-HGF)0$$aOssenkoppele, Rik$$b23
000887675 7001_ $$0P:(DE-HGF)0$$aOyen, Wim J G$$b24
000887675 7001_ $$0P:(DE-HGF)0$$aPerani, Daniela$$b25
000887675 7001_ $$0P:(DE-HGF)0$$aRabinovici, Gil D$$b26
000887675 7001_ $$0P:(DE-HGF)0$$aScheltens, Philip$$b27
000887675 7001_ $$0P:(DE-HGF)0$$aVillemagne, Victor L$$b28
000887675 7001_ $$0P:(DE-HGF)0$$aZetterberg, Henrik$$b29
000887675 7001_ $$0P:(DE-Juel1)177611$$aDrzezga, Alexander$$b30$$ufzj
000887675 773__ $$0PERI:(DE-600)2079704-7$$a10.1016/S1474-4422(20)30314-8$$gVol. 19, no. 11, p. 951 - 962$$n11$$p951 - 962$$tThe lancet <London> / Neurology$$v19$$x1474-4422$$y2020
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