Journal Article

FZJ-2020-04336

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias

Chételat, G. (Corresponding author) ; Arbizu, J. ; Barthel, H. ; Garibotto, V. ; Law, I. ; Morbelli, S. ; van de Giessen, E. ; Agosta, F. ; Barkhof, F. ; Brooks, D. J. ; Carrillo, M. C. ; Dubois, B. ; Fjell, A. M. ; Frisoni, G. B. ; Hansson, O. ; Herholz, K. ; Hutton, B. F. ; Jack, C. R. ; Lammertsma, A. A. ; Landau, S. M. ; Minoshima, S. ; Nobili, F. ; Nordberg, A. ; Ossenkoppele, R. ; Oyen, W. J. G. ; Perani, D. ; Rabinovici, G. D. ; Scheltens, P. ; Villemagne, V. L. ; Zetterberg, H. ; Drzezga, A.FZJ*

2020
Lancet Publ. Group London

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Please use a persistent id in citations: http://hdl.handle.net/2128/32284  doi:10.1016/S1474-4422(20)30314-8

Abstract: Various biomarkers are available to support the diagnosis of neurodegenerative diseases in clinical and research settings. Among the molecular imaging biomarkers, amyloid-PET, which assesses brain amyloid deposition, and 18F-fluorodeoxyglucose (18F-FDG) PET, which assesses glucose metabolism, provide valuable and complementary information. However, uncertainty remains regarding the optimal timepoint, combination, and an order in which these PET biomarkers should be used in diagnostic evaluations because conclusive evidence is missing. Following an expert panel discussion, we reached an agreement on the specific use of the individual biomarkers, based on available evidence and clinical expertise. We propose a diagnostic algorithm with optimal timepoints for these PET biomarkers, also taking into account evidence from other biomarkers, for early and differential diagnosis of neurodegenerative diseases that can lead to dementia. We propose three main diagnostic pathways with distinct biomarker sequences, in which amyloid-PET and 18F-FDG-PET are placed at different positions in the order of diagnostic evaluations, depending on clinical presentation. We hope that this algorithm can support diagnostic decision making in specialist clinical settings with access to these biomarkers and might stimulate further research towards optimal diagnostic strategies.

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Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)
2. 573 - Neuroimaging (POF3-573) (POF3-573)

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 25 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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