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000888034 1001_ $$00000-0002-1847-578X$$aHong, Seok-Jun$$b0$$eCorresponding author
000888034 245__ $$aAtypical functional connectome hierarchy in autism
000888034 260__ $$a[London]$$bNature Publishing Group UK$$c2019
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000888034 520__ $$aOne paradox of autism is the co-occurrence of deficits in sensory and higher-order socio-cognitive processing. Here, we examined whether these phenotypical patterns may relate to an overarching system-level imbalance-specifically a disruption in macroscale hierarchy affecting integration and segregation of unimodal and transmodal networks. Combining connectome gradient and stepwise connectivity analysis based on task-free functional magnetic resonance imaging (fMRI), we demonstrated atypical connectivity transitions between sensory and higher-order default mode regions in a large cohort of individuals with autism relative to typically-developing controls. Further analyses indicated that reduced differentiation related to perturbed stepwise connectivity from sensory towards transmodal areas, as well as atypical long-range rich-club connectivity. Supervised pattern learning revealed that hierarchical features predicted deficits in social cognition and low-level behavioral symptoms, but not communication-related symptoms. Our findings provide new evidence for imbalances in network hierarchy in autism, which offers a parsimonious reference frame to consolidate its diverse features.
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000888034 7001_ $$0P:(DE-HGF)0$$aVos de Wael, Reinder$$b1$$eCorresponding author
000888034 7001_ $$00000-0002-0714-0685$$aBethlehem, Richard A. I.$$b2
000888034 7001_ $$0P:(DE-HGF)0$$aLariviere, Sara$$b3
000888034 7001_ $$0P:(DE-HGF)0$$aPaquola, Casey$$b4
000888034 7001_ $$0P:(DE-Juel1)173843$$aValk, Sofie L.$$b5
000888034 7001_ $$0P:(DE-HGF)0$$aMilham, Michael P.$$b6
000888034 7001_ $$0P:(DE-HGF)0$$aDi Martino, Adriana$$b7
000888034 7001_ $$0P:(DE-HGF)0$$aMargulies, Daniel S.$$b8
000888034 7001_ $$0P:(DE-HGF)0$$aSmallwood, Jonathan$$b9
000888034 7001_ $$0P:(DE-HGF)0$$aBernhardt, Boris C.$$b10
000888034 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-019-08944-1$$gVol. 10, no. 1, p. 1022$$n1$$p1022$$tNature Communications$$v10$$x2041-1723$$y2019
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