Journal Article

FZJ-2020-04612

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Atypical functional connectome hierarchy in autism

Hong, S.-J. (Corresponding author) ; Vos de Wael, R. (Corresponding author) ; Bethlehem, R. A. I. ; Lariviere, S. ; Paquola, C. ; Valk, S. L.FZJ* ; Milham, M. P. ; Di Martino, A. ; Margulies, D. S. ; Smallwood, J. ; Bernhardt, B. C.

2019
Nature Publishing Group UK [London]

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Please use a persistent id in citations: http://hdl.handle.net/2128/26242  doi:10.1038/s41467-019-08944-1

Abstract: One paradox of autism is the co-occurrence of deficits in sensory and higher-order socio-cognitive processing. Here, we examined whether these phenotypical patterns may relate to an overarching system-level imbalance-specifically a disruption in macroscale hierarchy affecting integration and segregation of unimodal and transmodal networks. Combining connectome gradient and stepwise connectivity analysis based on task-free functional magnetic resonance imaging (fMRI), we demonstrated atypical connectivity transitions between sensory and higher-order default mode regions in a large cohort of individuals with autism relative to typically-developing controls. Further analyses indicated that reduced differentiation related to perturbed stepwise connectivity from sensory towards transmodal areas, as well as atypical long-range rich-club connectivity. Supervised pattern learning revealed that hierarchical features predicted deficits in social cognition and low-level behavioral symptoms, but not communication-related symptoms. Our findings provide new evidence for imbalances in network hierarchy in autism, which offers a parsimonious reference frame to consolidate its diverse features.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)

Appears in the scientific report 2020

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