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@ARTICLE{Hong:888034,
      author       = {Hong, Seok-Jun and Vos de Wael, Reinder and Bethlehem,
                      Richard A. I. and Lariviere, Sara and Paquola, Casey and
                      Valk, Sofie L. and Milham, Michael P. and Di Martino,
                      Adriana and Margulies, Daniel S. and Smallwood, Jonathan and
                      Bernhardt, Boris C.},
      title        = {{A}typical functional connectome hierarchy in autism},
      journal      = {Nature Communications},
      volume       = {10},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {FZJ-2020-04612},
      pages        = {1022},
      year         = {2019},
      abstract     = {One paradox of autism is the co-occurrence of deficits in
                      sensory and higher-order socio-cognitive processing. Here,
                      we examined whether these phenotypical patterns may relate
                      to an overarching system-level imbalance-specifically a
                      disruption in macroscale hierarchy affecting integration and
                      segregation of unimodal and transmodal networks. Combining
                      connectome gradient and stepwise connectivity analysis based
                      on task-free functional magnetic resonance imaging (fMRI),
                      we demonstrated atypical connectivity transitions between
                      sensory and higher-order default mode regions in a large
                      cohort of individuals with autism relative to
                      typically-developing controls. Further analyses indicated
                      that reduced differentiation related to perturbed stepwise
                      connectivity from sensory towards transmodal areas, as well
                      as atypical long-range rich-club connectivity. Supervised
                      pattern learning revealed that hierarchical features
                      predicted deficits in social cognition and low-level
                      behavioral symptoms, but not communication-related symptoms.
                      Our findings provide new evidence for imbalances in network
                      hierarchy in autism, which offers a parsimonious reference
                      frame to consolidate its diverse features.},
      cin          = {INM-7},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30833582},
      UT           = {WOS:000460125400004},
      doi          = {10.1038/s41467-019-08944-1},
      url          = {https://juser.fz-juelich.de/record/888034},
}