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| 001 | 888034 | ||
| 005 | 20210130010757.0 | ||
| 024 | 7 | _ | |a 10.1038/s41467-019-08944-1 |2 doi |
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| 037 | _ | _ | |a FZJ-2020-04612 |
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| 100 | 1 | _ | |a Hong, Seok-Jun |0 0000-0002-1847-578X |b 0 |e Corresponding author |
| 245 | _ | _ | |a Atypical functional connectome hierarchy in autism |
| 260 | _ | _ | |a [London] |c 2019 |b Nature Publishing Group UK |
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| 520 | _ | _ | |a One paradox of autism is the co-occurrence of deficits in sensory and higher-order socio-cognitive processing. Here, we examined whether these phenotypical patterns may relate to an overarching system-level imbalance-specifically a disruption in macroscale hierarchy affecting integration and segregation of unimodal and transmodal networks. Combining connectome gradient and stepwise connectivity analysis based on task-free functional magnetic resonance imaging (fMRI), we demonstrated atypical connectivity transitions between sensory and higher-order default mode regions in a large cohort of individuals with autism relative to typically-developing controls. Further analyses indicated that reduced differentiation related to perturbed stepwise connectivity from sensory towards transmodal areas, as well as atypical long-range rich-club connectivity. Supervised pattern learning revealed that hierarchical features predicted deficits in social cognition and low-level behavioral symptoms, but not communication-related symptoms. Our findings provide new evidence for imbalances in network hierarchy in autism, which offers a parsimonious reference frame to consolidate its diverse features. |
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| 700 | 1 | _ | |a Vos de Wael, Reinder |0 P:(DE-HGF)0 |b 1 |e Corresponding author |
| 700 | 1 | _ | |a Bethlehem, Richard A. I. |0 0000-0002-0714-0685 |b 2 |
| 700 | 1 | _ | |a Lariviere, Sara |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Paquola, Casey |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Valk, Sofie L. |0 P:(DE-Juel1)173843 |b 5 |
| 700 | 1 | _ | |a Milham, Michael P. |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Di Martino, Adriana |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Margulies, Daniel S. |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Smallwood, Jonathan |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Bernhardt, Boris C. |0 P:(DE-HGF)0 |b 10 |
| 773 | _ | _ | |a 10.1038/s41467-019-08944-1 |g Vol. 10, no. 1, p. 1022 |0 PERI:(DE-600)2553671-0 |n 1 |p 1022 |t Nature Communications |v 10 |y 2019 |x 2041-1723 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/888034/files/s41467-019-08944-1.pdf |y OpenAccess |
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