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@ARTICLE{Lothmann:888139,
      author       = {Lothmann, Kimberley and Deitersen, Jana and Zilles, Karl
                      and Amunts, Katrin and Herold, Christina},
      title        = {{N}ew boundaries and dissociation of the mouse hippocampus
                      along the dorsal‐ventral axis based on glutamatergic,
                      {GABA}ergic and catecholaminergic receptor densities},
      journal      = {Hippocampus},
      volume       = {31},
      number       = {1},
      issn         = {1098-1063},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {FZJ-2020-04713},
      pages        = {56-78},
      year         = {2021},
      abstract     = {In rodents, gene‐expression, neuronal tuning,
                      connectivity and neurogenesis studies have postulated that
                      the dorsal, the intermediate and the ventral hippocampal
                      formation (HF) are distinct entities. These findings are
                      underpinned by behavioral studies showing a dissociable role
                      of dorsal and ventral HF in learning, memory, stress and
                      emotional processing. However, up to now, the molecular
                      basis of such differences in relation to discrete boundaries
                      is largely unknown. Therefore, we analyzed binding site
                      densities for glutamatergic AMPA, NMDA, kainate and
                      mGluR2/3, GABAergic GABAA (including benzodiazepine binding
                      sites), GABAB, dopaminergic D1/5 and noradrenergic α1 and
                      α2 receptors as key modulators for signal transmission in
                      hippocampal functions, using quantitative in vitro receptor
                      autoradiography along the dorsal‐ventral axis of the mouse
                      HF. Beside general different receptor profiles of the
                      dentate gyrus (DG) and Cornu Ammonis fields (CA1, CA2, CA3,
                      CA4/hilus), we detected substantial differences between
                      dorsal, intermediate and ventral subdivisions and individual
                      layers for all investigated receptor types, except GABAB.
                      For example, striking higher densities of α2 receptors were
                      detected in the ventral DG, while the dorsal DG possesses
                      higher numbers of kainate, NMDA, GABAA and D1/5 receptors.
                      CA1 dorsal and intermediate subdivisions showed higher AMPA,
                      NMDA, mGluR2/3, GABAA, D1/5 receptors, while kainate
                      receptors are higher expressed in ventral CA1, and
                      noradrenergic α1 and α2 receptors in the intermediate
                      region of CA1. CA2 dorsal was distinguished by higher
                      kainate, α1 and α2 receptors in the intermediate region,
                      while CA3 showed a more complex dissociation. Our findings
                      resulted not only in a clear segmentation of the mouse
                      hippocampus along the dorsal‐ventral axis, but also
                      provides insights into the neurochemical basis and likely
                      associated physiological processes in hippocampal functions.
                      Therein, the presented data has a high impact for future
                      studies modeling and investigating dorsal, intermediate and
                      ventral hippocampal dysfunction in relation to
                      neurodegenerative diseases or psychiatric disorders.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / HBP SGA2 - Human Brain Project Specific Grant
                      Agreement 2 (785907) / HBP SGA3 - Human Brain Project
                      Specific Grant Agreement 3 (945539)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(EU-Grant)785907 /
                      G:(EU-Grant)945539},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32986281},
      UT           = {WOS:000573167300001},
      doi          = {10.1002/hipo.23262},
      url          = {https://juser.fz-juelich.de/record/888139},
}