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@ARTICLE{Lejko:888199,
      author       = {Lejko, Nena and Larabi, Daouia I. and Herrmann, Christoph
                      S. and Aleman, André and Ćurčić-Blake, Branislava},
      title        = {{A}lpha {P}ower and {F}unctional {C}onnectivity in
                      {C}ognitive {D}ecline: {A} {S}ystematic {R}eview and
                      {M}eta-{A}nalysis},
      journal      = {Journal of Alzheimer's disease},
      volume       = {78},
      number       = {3},
      issn         = {1875-8908},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {FZJ-2020-04753},
      pages        = {1047 - 1088},
      year         = {2020},
      note         = {This work was supported by ZonMw Memorabel(grant number
                      733050836). The authors thank N. M.Maurits for her comments
                      on earlier versions of themanuscript.Authors’ disclosures
                      available online
                      (https://www.j-alz.com/manuscript-disclosures/20-0962r1).SUPPLEMENTARY
                      MATERIALThe supplementary material is available in
                      theelectronic version of this article:
                      https://dx.doi.org/10.3233/JAD200962.},
      abstract     = {Abstract.Background: Mild cognitive impairment (MCI) is a
                      stage between expected age-related cognitive decline and
                      dementia.Dementias have been associated with changes in
                      neural oscillations across the frequency spectrum, including
                      the alpha range.Alpha is the most prominent rhythm in human
                      EEG and is best detected during awake resting state (RS).
                      Though severalstudies measured alpha power and
                      synchronization in MCI, findings have not yet been
                      integrated.Objective: To consolidate findings on power and
                      synchronization of alpha oscillations across stages of
                      cognitive decline.Methods: We included studies published
                      until January 2020 that compared power or functional
                      connectivity between 1)people with MCI and cognitively
                      healthy older adults (OA) or people with a neurodegenerative
                      dementia, and 2) people withprogressive and stable MCI.
                      Random-effects meta-analyses were performed when enough data
                      was available.Results: Sixty-eight studies were included in
                      the review. Global RS alpha power was lower in AD than in
                      MCI (ES = $–0.30;95\%$ CI = –0.51, –0.10; k = 6), and
                      in MCI than in OA (ES = –1.49; $95\%$ CI = –2.69,
                      –0.29; k = 5). However, the latter metaanalysisshould be
                      interpreted cautiously due to high heterogeneity. The review
                      showed lower RS alpha power in progressivethan in stable
                      MCI, and lower task-related alpha reactivity in MCI than in
                      OA. People with MCI had both lower and higherfunctional
                      connectivity than OA. Publications lacked consistency in MCI
                      diagnosis and EEG measures.Conclusion: Research indicates
                      that RS alpha power decreases with increasing impairment,
                      and could—combined withmeasures from other frequency
                      bands—become a biomarker of early cognitive
                      decline.keywords: Alpha rhythm, brain waves, dementia,
                      electroencephalography, mild cognitive impairment},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33185607},
      UT           = {WOS:000592832700016},
      doi          = {10.3233/JAD-200962},
      url          = {https://juser.fz-juelich.de/record/888199},
}