Journal Article

FZJ-2020-04753

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Alpha Power and Functional Connectivity in Cognitive Decline: A Systematic Review and Meta-Analysis

Lejko, N. (Corresponding author) ; Larabi, D. I.FZJ* ; Herrmann, C. S. ; Aleman, A. ; Ćurčić-Blake, B.

2020
IOS Press Amsterdam

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Please use a persistent id in citations: http://hdl.handle.net/2128/26285  doi:10.3233/JAD-200962

Abstract: Abstract.Background: Mild cognitive impairment (MCI) is a stage between expected age-related cognitive decline and dementia.Dementias have been associated with changes in neural oscillations across the frequency spectrum, including the alpha range.Alpha is the most prominent rhythm in human EEG and is best detected during awake resting state (RS). Though severalstudies measured alpha power and synchronization in MCI, findings have not yet been integrated.Objective: To consolidate findings on power and synchronization of alpha oscillations across stages of cognitive decline.Methods: We included studies published until January 2020 that compared power or functional connectivity between 1)people with MCI and cognitively healthy older adults (OA) or people with a neurodegenerative dementia, and 2) people withprogressive and stable MCI. Random-effects meta-analyses were performed when enough data was available.Results: Sixty-eight studies were included in the review. Global RS alpha power was lower in AD than in MCI (ES = –0.30;95% CI = –0.51, –0.10; k = 6), and in MCI than in OA (ES = –1.49; 95% CI = –2.69, –0.29; k = 5). However, the latter metaanalysisshould be interpreted cautiously due to high heterogeneity. The review showed lower RS alpha power in progressivethan in stable MCI, and lower task-related alpha reactivity in MCI than in OA. People with MCI had both lower and higherfunctional connectivity than OA. Publications lacked consistency in MCI diagnosis and EEG measures.Conclusion: Research indicates that RS alpha power decreases with increasing impairment, and could—combined withmeasures from other frequency bands—become a biomarker of early cognitive decline.keywords: Alpha rhythm, brain waves, dementia, electroencephalography, mild cognitive impairment

Note: This work was supported by ZonMw Memorabel(grant number 733050836). The authors thank N. M.Maurits for her comments on earlier versions of themanuscript.Authors’ disclosures available online (https://www.j-alz.com/manuscript-disclosures/20-0962r1).SUPPLEMENTARY MATERIALThe supplementary material is available in theelectronic version of this article: https://dx.doi.org/10.3233/JAD200962.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)

Appears in the scientific report 2020

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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