TY  - JOUR
AU  - Wolf, Nikolaus
AU  - Yuan, Xiaobo
AU  - Hassani, Hossein
AU  - Milos, Frano
AU  - Mayer, Dirk
AU  - Breuer, Uwe
AU  - Offenhäusser, Andreas
AU  - Wördenweber, Roger
TI  - Surface Functionalization of Platinum Electrodes with APTES for Bioelectronic Applications
JO  - ACS applied bio materials
VL  - 3
IS  - 10
SN  - 2576-6422
CY  - Washington, DC
PB  - ACS Publications
M1  - FZJ-2020-04799
SP  - 7113 - 7121
PY  - 2020
AB  - The interface between electronic components and biological objects plays a crucial role for the success of bioelectronic devices. Since the electronics typically include different elements such as an insulating substrate in combination with conducting electrodes, an important issue of bioelectronics involves tailoring and optimizing the interface for any envisioned applications. In this paper, we present a method for functionalizing insulating substrates (SiO2) and metallic electrodes (Pt) simultaneously with a stable monolayer of organic molecules ((3-aminopropyl)triethoxysilane (APTES)). This monolayer is characterized by a high molecule density, long term stability, and a positive surface net charge and most likely represents a self-assembled monolayer (SAM). It facilitates a conversion of bio-unfriendly Pt surfaces into biocompatible surfaces which allows cell growth (neurons) on both functionalized components, SiO2 and Pt, which is comparable to that of reference samples coated with poly-L-lysine (PLL). Moreover, the functionalization greatly improves the electronic cell-chip coupling thereby enabling the recording of action potential signals of several mV at APTES-functionalized Pt electrodes.
LB  - PUB:(DE-HGF)16
C6  - 35019371
UR  - <Go to ISI:>//WOS:000619799800053
DO  - DOI:10.1021/acsabm.0c00936
UR  - https://juser.fz-juelich.de/record/888252
ER  -