Journal Article

FZJ-2020-04799

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Surface Functionalization of Platinum Electrodes with APTES for Bioelectronic Applications

Wolf, N.FZJ* ; Yuan, X.FZJ* ; Hassani, H. ; Milos, F.FZJ* ; Mayer, D.FZJ* ; Breuer, U.FZJ* ; Offenhäusser, A. (Corresponding author)FZJ* ; Wördenweber, R. (Corresponding author)FZJ*

2020
ACS Publications Washington, DC

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Please use a persistent id in citations: doi:10.1021/acsabm.0c00936

Abstract: The interface between electronic components and biological objects plays a crucial role for the success of bioelectronic devices. Since the electronics typically include different elements such as an insulating substrate in combination with conducting electrodes, an important issue of bioelectronics involves tailoring and optimizing the interface for any envisioned applications. In this paper, we present a method for functionalizing insulating substrates (SiO2) and metallic electrodes (Pt) simultaneously with a stable monolayer of organic molecules ((3-aminopropyl)triethoxysilane (APTES)). This monolayer is characterized by a high molecule density, long term stability, and a positive surface net charge and most likely represents a self-assembled monolayer (SAM). It facilitates a conversion of bio-unfriendly Pt surfaces into biocompatible surfaces which allows cell growth (neurons) on both functionalized components, SiO2 and Pt, which is comparable to that of reference samples coated with poly-L-lysine (PLL). Moreover, the functionalization greatly improves the electronic cell-chip coupling thereby enabling the recording of action potential signals of several mV at APTES-functionalized Pt electrodes.

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Contributing Institute(s):

1. Bioelektronik (IBI-3)

Research Program(s):

1. 5244 - Information Processing in Neuronal Networks (POF4-524) (POF4-524)

Appears in the scientific report 2020

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Database coverage:
; SCOPUS

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