TY  - JOUR
AU  - Thieme, A.
AU  - Röske, S.
AU  - Faber, J.
AU  - Sulzer, P.
AU  - Minnerop, Martina
AU  - Elben, S.
AU  - Jacobi, H.
AU  - Reetz, K.
AU  - Dogan, I.
AU  - Barkhoff, M.
AU  - Konczak, J.
AU  - Wondzinski, E.
AU  - Siebler, M.
AU  - Hetze, S.
AU  - Müller, O.
AU  - Sure, U.
AU  - Schmahmann, J. D.
AU  - Klockgether, T.
AU  - Synofzik, M.
AU  - Timmann, D.
TI  - Reference values for the Cerebellar Cognitive Affective / Schahmann Syndrome Scale: Age and education matter
JO  - Brain
VL  - 144
IS  - 2
SN  - 0006-8950
CY  - Oxford
PB  - Oxford Univ. Press
M1  - FZJ-2020-04826
SP  - e20
PY  - 2021
AB  - During recent decades, many studies have yielded evidence for cerebellar involvement in cognitive, emotional and affective processes besides the well-known cerebellar contribution to motor performance and learning (Koziol et al., 2014; Marien et al., 2014; Van Overwalle et al., 2014; Strata, 2015; Adamaszek et al., 2017; Kansal et al., 2017; Guell et al., 2018; King et al., 2019). Cerebellar diseases can result in executive, linguistic and visuospatial dysfunctions as well as problems with the regulation of emotion and affect. This combination of non-motor symptoms has been named cerebellar cognitive affective/Schmahmann syndrome (CCAS) (Schmahmann and Sherman, 1998). For many years, diagnosis has relied on non-standardized bedside cognitive examination and, if available, detailed neuropsychological test batteries. A short and easily applicable bedside test (CCAS Scale), published by Hoche et al. (2018) in Brain, was developed to screen for CCAS and is already in widespread use. We therefore believe that it is important to share our recent findings that the reference values published by Hoche and colleagues may apply only within a limited age and education range, while their more universal application may lead to a substantial number of false-positive test results.
LB  - PUB:(DE-HGF)16
C6  - 33367632
UR  - <Go to ISI:>//WOS:000649446500007
DO  - DOI:10.1093/brain/awaa417
UR  - https://juser.fz-juelich.de/record/888306
ER  -