TY  - JOUR
AU  - Gomila, Alexandre M. J.
AU  - Rustler, Karin
AU  - Maleeva, Galyna
AU  - Nin-Hill, Alba
AU  - Wutz, Daniel
AU  - Bautista-Barrufet, Antoni
AU  - Rovira, Xavier
AU  - Bosch, Miquel
AU  - Mukhametova, Elvira
AU  - Petukhova, Elena
AU  - Ponomareva, Daria
AU  - Mukhamedyarov, Marat
AU  - Peiretti, Franck
AU  - Alfonso-Prieto, Mercedes
AU  - Rovira, Carme
AU  - König, Burkhard
AU  - Bregestovski, Piotr
AU  - Gorostiza, Pau
TI  - Photocontrol of Endogenous Glycine Receptors In Vivo
JO  - Cell chemical biology
VL  - 27
IS  - 11
SN  - 2451-9456
CY  - Amsterdam
PB  - Elsevier
M1  - FZJ-2020-04864
SP  - 1425 - 1433.e7
PY  - 2020
AB  - Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understanding inhibitory circuits in intact animals and to developing drug-based phototherapies.
LB  - PUB:(DE-HGF)16
C6  - 32846115
UR  - <Go to ISI:>//WOS:000592358500010
DO  - DOI:10.1016/j.chembiol.2020.08.005
UR  - https://juser.fz-juelich.de/record/888346
ER  -