Journal Article

FZJ-2020-04864

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Photocontrol of Endogenous Glycine Receptors In Vivo

Gomila, A. M. J.Extern* ; Rustler, K. ; Maleeva, G. ; Nin-Hill, A. ; Wutz, D. ; Bautista-Barrufet, A. ; Rovira, X.Extern* ; Bosch, M.Extern* ; Mukhametova, E. ; Petukhova, E. ; Ponomareva, D. ; Mukhamedyarov, M. ; Peiretti, F. ; Alfonso-Prieto, M.FZJ* ; Rovira, C. (Corresponding author)Extern* ; König, B. (Corresponding author)Extern* ; Bregestovski, P. (Corresponding author)Extern* ; Gorostiza, P. (Corresponding author)Extern*

2020
Elsevier Amsterdam

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Please use a persistent id in citations: http://hdl.handle.net/2128/26847  doi:10.1016/j.chembiol.2020.08.005

Abstract: Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understanding inhibitory circuits in intact animals and to developing drug-based phototherapies.

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Contributing Institute(s):

1. Computational Biomedicine (IAS-5)
2. Computational Biomedicine (INM-9)

Research Program(s):

1. 571 - Connectivity and Activity (POF3-571) (POF3-571)
2. 574 - Theory, modelling and simulation (POF3-574) (POF3-574)

Appears in the scientific report 2020

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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