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@ARTICLE{Gomila:888346,
      author       = {Gomila, Alexandre M. J. and Rustler, Karin and Maleeva,
                      Galyna and Nin-Hill, Alba and Wutz, Daniel and
                      Bautista-Barrufet, Antoni and Rovira, Xavier and Bosch,
                      Miquel and Mukhametova, Elvira and Petukhova, Elena and
                      Ponomareva, Daria and Mukhamedyarov, Marat and Peiretti,
                      Franck and Alfonso-Prieto, Mercedes and Rovira, Carme and
                      König, Burkhard and Bregestovski, Piotr and Gorostiza, Pau},
      title        = {{P}hotocontrol of {E}ndogenous {G}lycine {R}eceptors
                      {I}n {V}ivo},
      journal      = {Cell chemical biology},
      volume       = {27},
      number       = {11},
      issn         = {2451-9456},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {FZJ-2020-04864},
      pages        = {1425 - 1433.e7},
      year         = {2020},
      abstract     = {Glycine receptors (GlyRs) are indispensable for maintaining
                      excitatory/inhibitory balance in neuronal circuits that
                      control reflexes and rhythmic motor behaviors. Here we have
                      developed Glyght, a GlyR ligand controlled with light. It is
                      selective over other Cys-loop receptors, is active in vivo,
                      and displays an allosteric mechanism of action. The
                      photomanipulation of glycinergic neurotransmission opens new
                      avenues to understanding inhibitory circuits in intact
                      animals and to developing drug-based phototherapies.},
      cin          = {IAS-5 / INM-9},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IAS-5-20120330 / I:(DE-Juel1)INM-9-20140121},
      pnm          = {571 - Connectivity and Activity (POF3-571) / 574 - Theory,
                      modelling and simulation (POF3-574)},
      pid          = {G:(DE-HGF)POF3-571 / G:(DE-HGF)POF3-574},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32846115},
      UT           = {WOS:000592358500010},
      doi          = {10.1016/j.chembiol.2020.08.005},
      url          = {https://juser.fz-juelich.de/record/888346},
}