TY  - JOUR
AU  - Weiss Lucas, Carolin
AU  - Nettekoven, Charlotte
AU  - Neuschmelting, Volker
AU  - Oros‐Peusquens, Ana‐Maria
AU  - Stoffels, Gabriele
AU  - Viswanathan, Shivakumar
AU  - Rehme, Anne K.
AU  - Faymonville, Andrea Maria
AU  - Shah, N. Jon
AU  - Langen, Karl Josef
AU  - Goldbrunner, Roland
AU  - Grefkes, Christian
TI  - Invasive versus non‐invasive mapping of the motor cortex
JO  - Human brain mapping
VL  - 41
IS  - 14
SN  - 1097-0193
CY  - New York, NY
PB  - Wiley-Liss
M1  - FZJ-2020-05084
SP  - 3970 - 3983
PY  - 2020
AB  - Precise and comprehensive mapping of somatotopic representations in the motor cortex is clinically essential to achieve maximum resection of brain tumours whilst preserving motor function, especially since the current gold standard, that is, intraoperative direct cortical stimulation (DCS), holds limitations linked to the intraoperative setting such as time constraints or anatomical restrictions. Non‐invasive techniques are increasingly relevant with regard to pre‐operative risk‐assessment. Here, we assessed the congruency of neuronavigated transcranial magnetic stimulation (nTMS) and functional magnetic resonance imaging (fMRI) with DCS. The motor representations of the hand, the foot and the tongue regions of 36 patients with intracranial tumours were mapped pre‐operatively using nTMS and fMRI and by intraoperative DCS. Euclidean distances (ED) between hotspots/centres of gravity and (relative) overlaps of the maps were compared. We found significantly smaller EDs (11.4 ± 8.3 vs. 16.8 ± 7.0 mm) and better spatial overlaps (64 ± 38% vs. 37 ± 37%) between DCS and nTMS compared with DCS and fMRI. In contrast to DCS, fMRI and nTMS mappings were feasible for all regions and patients without complications. In summary, nTMS seems to be the more promising non‐invasive motor cortex mapping technique to approximate the gold standard DCS results.
LB  - PUB:(DE-HGF)16
C6  - pmid:32588936
UR  - <Go to ISI:>//WOS:000543223500001
DO  - DOI:10.1002/hbm.25101
UR  - https://juser.fz-juelich.de/record/888641
ER  -