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@ARTICLE{Xu:889305,
      author       = {Xu, Anna and Larsen, Bart and Henn, Alina and Baller, Erica
                      B. and Scott, J. Cobb and Sharma, Vaishnavi and Adebimpe,
                      Azeez and Basbaum, Allan I. and Corder, Gregory and Dworkin,
                      Robert H. and Edwards, Robert R. and Woolf, Clifford J. and
                      Eickhoff, Simon B. and Eickhoff, Claudia R. and
                      Satterthwaite, Theodore D.},
      title        = {{B}rain {R}esponses to {N}oxious {S}timuli in {P}atients
                      {W}ith {C}hronic {P}ain},
      journal      = {JAMA network open},
      volume       = {4},
      number       = {1},
      issn         = {2574-3805},
      address      = {Chicago, Ill.},
      publisher    = {American Medical Association},
      reportid     = {FZJ-2021-00197},
      pages        = {e2032236},
      year         = {2021},
      abstract     = {Importance Functional neuroimaging is a valuable tool for
                      understanding how patients with chronic pain respond to
                      painful stimuli. However, past studies have reported
                      heterogenous results, highlighting opportunities for a
                      quantitative meta-analysis to integrate existing data and
                      delineate consistent associations across studies.Objective
                      To identify differential brain responses to noxious stimuli
                      in patients with chronic pain using functional magnetic
                      resonance imaging (fMRI) while adhering to current best
                      practices for neuroimaging meta-analyses.Data Sources All
                      fMRI experiments published from January 1, 1990, to May 28,
                      2019, were identified in a literature search of
                      PubMed/MEDLINE, EMBASE, Web of Science, Cochrane Library,
                      PsycINFO, and SCOPUS.Study Selection Experiments comparing
                      brain responses to noxious stimuli in fMRI between patients
                      and controls were selected if they reported whole-brain
                      results, included at least 10 patients and 10 healthy
                      control participants, and used adequate statistical
                      thresholding (voxel-height P < .001 or cluster-corrected
                      P < .05). Two independent reviewers evaluated titles and
                      abstracts returned by the search. In total, 3682 abstracts
                      were screened, and 1129 full-text articles were
                      evaluated.Data Extraction and Synthesis Thirty-seven
                      experiments from 29 articles met inclusion criteria for
                      meta-analysis. Coordinates reporting significant activation
                      differences between patients with chronic pain and healthy
                      controls were extracted. These data were meta-analyzed using
                      activation likelihood estimation. Data were analyzed from
                      December 2019 to February 2020.Main Outcomes and Measures A
                      whole-brain meta-analysis evaluated whether reported
                      differences in brain activation in response to noxious
                      stimuli between patients and healthy controls were spatially
                      convergent. Follow-up analyses examined the directionality
                      of any differences. Finally, an exploratory
                      (nonpreregistered) region-of-interest analysis examined
                      differences within the pain network.Results The 37
                      experiments from 29 unique articles included a total of 511
                      patients and 433 controls (944 participants). Whole-brain
                      meta-analyses did not reveal significant differences between
                      patients and controls in brain responses to noxious stimuli
                      at the preregistered statistical threshold. However,
                      exploratory analyses restricted to the pain network revealed
                      aberrant activity in patients.Conclusions and Relevance In
                      this systematic review and meta-analysis, preregistered,
                      whole-brain analyses did not reveal aberrant fMRI activity
                      in patients with chronic pain. Exploratory analyses
                      suggested that subtle, spatially diffuse differences may
                      exist within the pain network. Future work on chronic pain
                      biomarkers may benefit from focus on this core set of
                      pain-responsive areas.},
      cin          = {INM-7 / INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-1-20090406},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-525},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33399857},
      UT           = {WOS:000610371800003},
      doi          = {10.1001/jamanetworkopen.2020.32236},
      url          = {https://juser.fz-juelich.de/record/889305},
}