TY  - JOUR
AU  - Schirò, Giorgio
AU  - Fichou, Yann
AU  - Brogan, Alex P. S.
AU  - Sessions, Richard
AU  - Lohstroh, Wiebke
AU  - Zamponi, Michaela
AU  - Schneider, Gerald J.
AU  - Gallat, François-Xavier
AU  - Paciaroni, Alessandro
AU  - Tobias, Douglas J.
AU  - Perriman, Adam
AU  - Weik, Martin
TI  - Diffusivelike Motions in a Solvent-Free Protein-Polymer Hybrid
JO  - Physical review letters
VL  - 126
IS  - 8
SN  - 1079-7114
CY  - College Park, Md.
PB  - APS
M1  - FZJ-2021-01245
SP  - 088102
PY  - 2021
AB  - The interaction between proteins and hydration water stabilizes protein structure and promotes functional dynamics, with water translational motions enabling protein flexibility. Engineered solvent-free protein-polymer hybrids have been shown to preserve protein structure, function, and dynamics. Here, we used neutron scattering, protein and polymer perdeuteration, and molecular dynamics simulations to explore how a polymer dynamically replaces water. Even though relaxation rates and vibrational properties are strongly modified in polymer coated compared to hydrated proteins, liquidlike polymer dynamics appear to plasticize the conjugated protein in a qualitatively similar way as do hydration-water translational motions.
LB  - PUB:(DE-HGF)16
C6  - 33709739
UR  - <Go to ISI:>//WOS:000621595400014
DO  - DOI:10.1103/PhysRevLett.126.088102
UR  - https://juser.fz-juelich.de/record/890914
ER  -