Journal Article

FZJ-2021-01245

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Diffusivelike Motions in a Solvent-Free Protein-Polymer Hybrid

Schirò, G. (Corresponding author) ; Fichou, Y. (Corresponding author) ; Brogan, A. P. S. ; Sessions, R. ; Lohstroh, W. ; Zamponi, M.FZJ* ; Schneider, G. J. ; Gallat, F.-X. ; Paciaroni, A. ; Tobias, D. J. ; Perriman, A. ; Weik, M. (Corresponding author)

2021
APS College Park, Md.

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Please use a persistent id in citations: http://hdl.handle.net/2128/28019  doi:10.1103/PhysRevLett.126.088102

Abstract: The interaction between proteins and hydration water stabilizes protein structure and promotes functional dynamics, with water translational motions enabling protein flexibility. Engineered solvent-free protein-polymer hybrids have been shown to preserve protein structure, function, and dynamics. Here, we used neutron scattering, protein and polymer perdeuteration, and molecular dynamics simulations to explore how a polymer dynamically replaces water. Even though relaxation rates and vibrational properties are strongly modified in polymer coated compared to hydrated proteins, liquidlike polymer dynamics appear to plasticize the conjugated protein in a qualitatively similar way as do hydration-water translational motions.

Keyword(s): Health and Life (1st) ; Biology (2nd)

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Contributing Institute(s):

1. JCNS-FRM-II (JCNS-FRM-II)
2. Neutronenstreuung (JCNS-1)
3. JCNS-4 (JCNS-4)
4. Heinz Maier-Leibnitz Zentrum (MLZ)

Research Program(s):

1. 6G4 - Jülich Centre for Neutron Research (JCNS) (FZJ) (POF4-6G4) (POF4-6G4)
2. 632 - Materials – Quantum, Complex and Functional Materials (POF4-632) (POF4-632)

Experiment(s):

1. SPHERES: Backscattering spectrometer (NL6S)
2. TOFTOF: Cold neutron time-of-flight spectrometer (NL2au)

Appears in the scientific report 2021

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Database coverage:
; ; Clarivate Analytics Master Journal List ; Current Contents - Electronics and Telecommunications Collection ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOAP3 sponsored Journal ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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