Contribution to a conference proceedings/Contribution to a book

FZJ-2021-01633

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Numerical Analysis of Oscillatory Flows in the Human Brain by a Lattice-Boltzmann Method

Koh, S.-R. (Corresponding author)FZJ* ; Kim, J. ; Lintermann, A.FZJ*

2021

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Please use a persistent id in citations: http://hdl.handle.net/2128/27568  doi:10.23967/wccm-eccomas.2020.226

Abstract: The cerebrospinal fluid flow in a brain ventricular system is analyzed by the numerical approach employing a lattice-Boltzmann (LB) method. The cerebrospinal fluid, which surrounds the human brain and spinal cord, fills the cerebral ventricles as well as the cranial and subarachnoid spaces. Diseases in a central nerve system disrupt the flow circulation which influences on a number of vital functions. A computational fluid dynamics technique is used to determine the member geometry impact on the flow motion. The numerical analysis focuses on building a simulation-based basis for testing/optimizing therapeutical methods and understanding the pathophysiology. Magnetic resonance (MR) imaging is exploited to obtain realistic geometries in a brain ventricular system. The computational domain is discretized by a hierarchical Cartesian octree mesh. The numerical procedure based on an LB method overcomes the difficulties raised by typical finite-difference and finite-volume methods on high-performance computing (HPC) systems. An oscillating flow boundary condition is defined to resolve the kinetic behavior of cerebrospinal fluid in a cardiac cycle. The three-dimensional structures captured in the cerebral ventricles show a qualitative agreement with an observation based on an MR velocity mapping. The simulation on a HPC system is able to provide further insights into the transport from brain to spinal cord.

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Contributing Institute(s):

1. Jülich Supercomputing Center (JSC)

Research Program(s):

1. 5111 - Domain-Specific Simulation & Data Life Cycle Labs (SDLs) and Research Groups (POF4-511) (POF4-511)

Appears in the scientific report 2021

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Database coverage:
; ; BIOSIS Previews ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection ; Zoological Record

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