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@ARTICLE{Jost:893091,
      author       = {Jost, Stefanie T. and Visser-Vandewalle, Veerle and Rizos,
                      Alexandra and Loehrer, Philipp A. and Silverdale, Monty and
                      Evans, Julian and Samuel, Michael and Petry-Schmelzer, Jan
                      Niklas and Sauerbier, Anna and Gronostay, Alexandra and
                      Barbe, Michael T. and Fink, Gereon Rudolf and Ashkan,
                      Keyoumars and Antonini, Angelo and Martinez-Martin, Pablo
                      and Chaudhuri, K. Ray and Timmermann, Lars and Dafsari,
                      Haidar S. and Bhidayasiri, Roongroj and Falup-Pecurariu,
                      Cristian and Jeon, Beomseok and Leta, Valentina and
                      Borghammer, Per and Odin, Per and Schrag, Anette and Storch,
                      Alexander and Violante, Mayela Rodriguez and Weintraub,
                      Daniel and Adler, Charles and Barone, Paolo and Brooks,
                      David J. and Brown, Richard and Cantillon, Marc and Carroll,
                      Camille and Coelho, Miguel and Henriksen, Tove and Hu,
                      Michele and Jenner, Peter and Kramberger, Milica and Kumar,
                      Padma and Kurtis, Mónica and Lewis, Simon and Litvan, Irene
                      and Lyons, Kelly and Martino, Davide and Masellis, Mario and
                      Mochizuki, Hideki and Morley, James F. and Nirenberg,
                      Melissa and Pagonabarraga, Javier and Panicker, Jalesh and
                      Pavese, Nicola and Pekkonen, Eero and Postuma, Ron and
                      Rosales, Raymond and Schapira, Anthony and Simuni, Tanya and
                      Stocchi, Fabrizio and Subramanian, Indu and Tagliati,
                      Michele and Tinazzi, Michele and Toledo, Jon and Tsuboi,
                      Yoshio and Walker, Richard},
      title        = {{N}on-motor predictors of 36-month quality of life after
                      subthalamic stimulation in {P}arkinson disease},
      journal      = {npj Parkinson's Disease},
      volume       = {7},
      number       = {1},
      issn         = {2373-8057},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {FZJ-2021-02551},
      pages        = {48},
      year         = {2021},
      abstract     = {To identify predictors of 36-month follow-up quality of
                      life (QoL) outcome after bilateral subthalamic nucleus deep
                      brain stimulation (STN-DBS) in Parkinson’s disease (PD).
                      In this ongoing, prospective, multicenter international
                      study (Cologne, Manchester, London) including 73 patients
                      undergoing STN-DBS, we assessed the following scales
                      preoperatively and at 6-month and 36-month follow-up: PD
                      Questionnaire-8 (PDQ-8), NMSScale (NMSS), Scales for
                      Outcomes in PD (SCOPA)-motor examination, -activities of
                      daily living, and -complications, and levodopa equivalent
                      daily dose (LEDD). We analyzed factors associated with QoL
                      improvement at 36-month follow-up based on (1) correlations
                      between baseline test scores and QoL improvement, (2)
                      step-wise linear regressions with baseline test scores as
                      independent and QoL improvement as dependent variables, (3)
                      logistic regressions and receiver operating characteristic
                      curves using a dichotomized variable “QoL
                      responders”/“non-responders”. At both follow-ups, NMSS
                      total score, SCOPA-motor examination, and -complications
                      improved and LEDD was reduced significantly. PDQ-8 improved
                      at 6-month follow-up with subsequent decrements in gains at
                      36-month follow-up when $61.6\%$ of patients were
                      categorized as “QoL non-responders”. Correlations,
                      linear, and logistic regression analyses found greater PDQ-8
                      improvements in patients with younger age, worse PDQ-8, and
                      worse specific NMS at baseline, such as ‘difficulties
                      experiencing pleasure’ and ‘problems sustaining
                      concentration’. Baseline SCOPA scores were not associated
                      with PDQ-8 changes. Our results provide evidence that
                      36-month QoL changes depend on baseline neuropsychological
                      and neuropsychiatric non-motor symptoms burden. These
                      findings highlight the need for an assessment of a wide
                      range of non-motor and motor symptoms when advising and
                      selecting individuals for DBS therapy.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-525},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34103534},
      UT           = {WOS:000659233200001},
      doi          = {10.1038/s41531-021-00174-x},
      url          = {https://juser.fz-juelich.de/record/893091},
}