Journal Article

FZJ-2021-02551

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease

Jost, S. T. (Corresponding author) ; Visser-Vandewalle, V. ; Rizos, A. ; Loehrer, P. A. ; Silverdale, M. ; Evans, J. ; Samuel, M. ; Petry-Schmelzer, J. N. ; Sauerbier, A. ; Gronostay, A. ; Barbe, M. T. ; Fink, G. R.FZJ* ; Ashkan, K. ; Antonini, A. ; Martinez-Martin, P. ; Chaudhuri, K. R. ; Timmermann, L. ; Dafsari, H. S. (Corresponding author) ; Bhidayasiri, R. ; Falup-Pecurariu, C. ; Jeon, B. ; Leta, V. ; Borghammer, P. ; Odin, P. ; Schrag, A. ; Storch, A. ; Violante, M. R. ; Weintraub, D. ; Adler, C. ; Barone, P. ; Brooks, D. J. ; Brown, R. ; Cantillon, M. ; Carroll, C. ; Coelho, M. ; Henriksen, T. ; Hu, M. ; Jenner, P. ; Kramberger, M. ; Kumar, P. ; Kurtis, M. ; Lewis, S. ; Litvan, I. ; Lyons, K. ; Martino, D. ; Masellis, M. ; Mochizuki, H. ; Morley, J. F. ; Nirenberg, M. ; Pagonabarraga, J. ; Panicker, J. ; Pavese, N. ; Pekkonen, E. ; Postuma, R. ; Rosales, R. ; Schapira, A. ; Simuni, T. ; Stocchi, F. ; Subramanian, I. ; Tagliati, M. ; Tinazzi, M. ; Toledo, J. ; Tsuboi, Y. ; Walker, R.

2021
Nature Publ. Group London [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/27915  doi:10.1038/s41531-021-00174-x

Abstract: To identify predictors of 36-month follow-up quality of life (QoL) outcome after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease (PD). In this ongoing, prospective, multicenter international study (Cologne, Manchester, London) including 73 patients undergoing STN-DBS, we assessed the following scales preoperatively and at 6-month and 36-month follow-up: PD Questionnaire-8 (PDQ-8), NMSScale (NMSS), Scales for Outcomes in PD (SCOPA)-motor examination, -activities of daily living, and -complications, and levodopa equivalent daily dose (LEDD). We analyzed factors associated with QoL improvement at 36-month follow-up based on (1) correlations between baseline test scores and QoL improvement, (2) step-wise linear regressions with baseline test scores as independent and QoL improvement as dependent variables, (3) logistic regressions and receiver operating characteristic curves using a dichotomized variable “QoL responders”/“non-responders”. At both follow-ups, NMSS total score, SCOPA-motor examination, and -complications improved and LEDD was reduced significantly. PDQ-8 improved at 6-month follow-up with subsequent decrements in gains at 36-month follow-up when 61.6% of patients were categorized as “QoL non-responders”. Correlations, linear, and logistic regression analyses found greater PDQ-8 improvements in patients with younger age, worse PDQ-8, and worse specific NMS at baseline, such as ‘difficulties experiencing pleasure’ and ‘problems sustaining concentration’. Baseline SCOPA scores were not associated with PDQ-8 changes. Our results provide evidence that 36-month QoL changes depend on baseline neuropsychological and neuropsychiatric non-motor symptoms burden. These findings highlight the need for an assessment of a wide range of non-motor and motor symptoms when advising and selecting individuals for DBS therapy.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 525 - Decoding Brain Organization and Dysfunction (POF4-525) (POF4-525)

Appears in the scientific report 2021

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