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| Hauptseite > Publikationsdatenbank > Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease > print |
| Hauptseite > Publikationsdatenbank > Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease > print |
| 001 | 893091 | ||
| 005 | 20210628150955.0 | ||
| 024 | 7 | _ | |a 10.1038/s41531-021-00174-x |2 doi |
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| 037 | _ | _ | |a FZJ-2021-02551 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Jost, Stefanie T. |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease |
| 260 | _ | _ | |a London [u.a.] |c 2021 |b Nature Publ. Group |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1623220602_9210 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a To identify predictors of 36-month follow-up quality of life (QoL) outcome after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease (PD). In this ongoing, prospective, multicenter international study (Cologne, Manchester, London) including 73 patients undergoing STN-DBS, we assessed the following scales preoperatively and at 6-month and 36-month follow-up: PD Questionnaire-8 (PDQ-8), NMSScale (NMSS), Scales for Outcomes in PD (SCOPA)-motor examination, -activities of daily living, and -complications, and levodopa equivalent daily dose (LEDD). We analyzed factors associated with QoL improvement at 36-month follow-up based on (1) correlations between baseline test scores and QoL improvement, (2) step-wise linear regressions with baseline test scores as independent and QoL improvement as dependent variables, (3) logistic regressions and receiver operating characteristic curves using a dichotomized variable “QoL responders”/“non-responders”. At both follow-ups, NMSS total score, SCOPA-motor examination, and -complications improved and LEDD was reduced significantly. PDQ-8 improved at 6-month follow-up with subsequent decrements in gains at 36-month follow-up when 61.6% of patients were categorized as “QoL non-responders”. Correlations, linear, and logistic regression analyses found greater PDQ-8 improvements in patients with younger age, worse PDQ-8, and worse specific NMS at baseline, such as ‘difficulties experiencing pleasure’ and ‘problems sustaining concentration’. Baseline SCOPA scores were not associated with PDQ-8 changes. Our results provide evidence that 36-month QoL changes depend on baseline neuropsychological and neuropsychiatric non-motor symptoms burden. These findings highlight the need for an assessment of a wide range of non-motor and motor symptoms when advising and selecting individuals for DBS therapy. |
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| 773 | _ | _ | |a 10.1038/s41531-021-00174-x |g Vol. 7, no. 1, p. 48 |0 PERI:(DE-600)2819218-7 |n 1 |p 48 |t npj Parkinson's Disease |v 7 |y 2021 |x 2373-8057 |
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